PMID- 26195047
OWN - NLM
STAT- MEDLINE
DCOM- 20160429
LR  - 20220317
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 4
IP  - 4
DP  - 2015 Jul
TI  - Relation of quantitative visual and neurologic outcomes to fatigue in multiple 
      sclerosis.
PG  - 304-10
LID - S2211-0348(15)00065-6 [pii]
LID - 10.1016/j.msard.2015.05.005 [doi]
AB  - BACKGROUND: The relation of fatigue in multiple sclerosis (MS) to the visual 
      system, an emerging structural and functional surrogate in MS, has not been well 
      established. OBJECTIVE: We examined how physical and cognitive fatigue could be 
      associated with visual dysfunction and neurologic impairment. METHODS: At a 
      single time-point, we assessed 143 patients with: Low-contrast letter acuity 
      (LCLA) and high-contrast visual acuity (VA) testing, the 25-Item National Eye 
      Institute Visual Functioning Questionnaire (NEI-VFQ-25) and Neuro-Ophthalmic 
      Supplement, the Modified Fatigue Impact Scale (MFIS), the MS Functional Composite 
      (MSFC), and the Expanded Disability Status Scale (EDSS). RESULTS: Worse binocular 
      LCLA scores were associated with increased levels of total and physical fatigue 
      (p</=0.026). Greater levels of fatigue were also associated with reduced 
      vision-specific QOL (p<0.001). Patients with more physical, but not cognitive, 
      fatigue had greater levels of impairment by the Timed 25-Foot Walk (T25W, r=0.39, 
      p<0.001), 9-Hole Peg Test (9HP r=0.22, p=0.011) and EDSS (r=0.45, p<0.001). 
      CONCLUSIONS: Reduced vision in MS is highly associated with physical fatigue and 
      could be used to capture more global, difficult to describe, symptoms. The 
      potential differences in physical vs. cognitive fatigue and their correlates may 
      begin to provide insight into their underlying mechanisms.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Chahin, Salim
AU  - Chahin S
AD  - Department of Neurology, University of Pennsylvania, 3400 Spruce St. 3. W. Gates, 
      Philadelphia, PA 19104, USA. Electronic address: salim.chahin@uphs.upenn.edu.
FAU - Miller, Deborah
AU  - Miller D
AD  - Department of Neurology, Cleveland Clinic Foundation, 1950 E 89th St, Cleveland, 
      OH 44106, USA. Electronic address: millerd@ccf.org.
FAU - Sakai, Reiko E
AU  - Sakai RE
AD  - University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, 
      USA. Electronic address: reiko.sakai@med.uvm.edu.
FAU - Wilson, James A
AU  - Wilson JA
AD  - Department of Neurology, University of Pennsylvania, 3400 Spruce St. 3. W. Gates, 
      Philadelphia, PA 19104, USA. Electronic address: jawilson@mail.med.upenn.edu.
FAU - Frohman, Teresa
AU  - Frohman T
AD  - Department of Neurology, University of Texas Southwestern Medical Center, 5323 
      Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address: 
      Teresa.Frohman@UTSouthwestern.edu.
FAU - Markowitz, Clyde
AU  - Markowitz C
AD  - Department of Neurology, University of Pennsylvania, 3400 Spruce St. 3. W. Gates, 
      Philadelphia, PA 19104, USA. Electronic address: cmarkowi@mail.med.upenn.edu.
FAU - Jacobs, Dina
AU  - Jacobs D
AD  - Department of Neurology, University of Pennsylvania, 3400 Spruce St. 3. W. Gates, 
      Philadelphia, PA 19104, USA. Electronic address: Dina.Jacobs2@uphs.upenn.edu.
FAU - Green, Ari
AU  - Green A
AD  - Department of Neurology, University of California at San Francisco, 1500 Owens St 
      #320, San Francisco, CA 94158, USA. Electronic address: agreen@ucsf.edu.
FAU - Calabresi, Peter A
AU  - Calabresi PA
AD  - Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe St, 
      Baltimore, MD 21287, USA. Electronic address: pcalabr1@jhmi.edu.
FAU - Frohman, Elliot M
AU  - Frohman EM
AD  - Department of Neurology, University of Texas Southwestern Medical Center, 5323 
      Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address: 
      Elliot.Frohman@UTSouthwestern.edu.
FAU - Galetta, Steven L
AU  - Galetta SL
AD  - Department of Neurology, New York University School of Medicine, 240 East 38th 
      Street, 20th Floor, New York, NY 10016, USA. Electronic address: 
      Steven.Galetta@nyumc.org.
FAU - Balcer, Laura J
AU  - Balcer LJ
AD  - Departments of Neurology and Population Health, New York University School of 
      Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA. Electronic 
      address: Laura.Balcer@nyumc.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150521
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
SB  - IM
MH  - Adult
MH  - Cognition Disorders/complications/physiopathology
MH  - Cross-Sectional Studies
MH  - Disability Evaluation
MH  - Fatigue/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/complications/*physiopathology
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Vision Disorders/complications/*physiopathology
MH  - Visual Acuity
OTO - NOTNLM
OT  - Disability
OT  - Fatigue
OT  - Low-contrast acuity
OT  - Multiple sclerosis
OT  - Quality of life
OT  - Vision
EDAT- 2015/07/22 06:00
MHDA- 2016/04/30 06:00
CRDT- 2015/07/22 06:00
PHST- 2014/09/08 00:00 [received]
PHST- 2015/02/21 00:00 [revised]
PHST- 2015/05/12 00:00 [accepted]
PHST- 2015/07/22 06:00 [entrez]
PHST- 2015/07/22 06:00 [pubmed]
PHST- 2016/04/30 06:00 [medline]
AID - S2211-0348(15)00065-6 [pii]
AID - 10.1016/j.msard.2015.05.005 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2015 Jul;4(4):304-10. doi: 10.1016/j.msard.2015.05.005. 
      Epub 2015 May 21.