PMID- 26195441
OWN - NLM
STAT- MEDLINE
DCOM- 20151217
LR  - 20150911
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 115
IP  - 3
DP  - 2015 Sep
TI  - Relation of lung function and current inhalant allergen-specific immunoglobulin E 
      concentrations in adolescents (GINIplus cohort).
PG  - 183-90
LID - S1081-1206(15)00407-X [pii]
LID - 10.1016/j.anai.2015.06.016 [doi]
AB  - BACKGROUND: The prevalence of allergen sensitization reaches up to 46.6% in 14- 
      to 17-year-old German adolescents. Polysensitization is strongly associated with 
      a higher risk of allergic rhinitis or asthma. Whether or how sensitization also 
      is related to lung function remains uncertain. OBJECTIVE: To assess whether 
      sensitization to common inhalant allergens is associated with lung function in 
      adolescents after stratification by allergic respiratory disease. METHODS: In 
      total, 1,719 15-year-old participants of the German Infant Study on the Influence 
      of Nutrition Intervention plus Air Pollution and Genetics on Allergy Development 
      (GINIplus) birth cohort provided valid spirometric indices, including forced 
      expiratory volume in 1 second, forced vital capacity (FVC), forced expiratory 
      flow rate at 25% to 75% of the FVC, and specific immunoglobulin E (IgE) screening 
      test to 8 inhalant allergens (ImmunoCAP). Complete information on allergic 
      rhinitis and asthma status was available for 1,128 subjects. Associations between 
      lung function parameters and sensitization, classified into 4 groups (no 
      sensitization to polysensitization) were analyzed using adjusted linear 
      regression models. RESULTS: Among participants, 21.1% (n = 347) had allergic 
      rhinitis, 10.1% (n = 119) had asthma, and 46.4% (n = 798) had a positive 
      screening test to inhalant allergens. Prevalences were consistently higher in 
      boys. The percentage of subjects with rhinitis or asthma increased from 5.8% in 
      non-sensitized subjects (n = 620) to 69.4% in polysensitized subjects (n = 144). 
      Sensitization was not associated with any spirometric parameter considered in 
      subjects with allergic rhinitis, asthma, or neither disease. CONCLUSION: Although 
      allergen-specific IgE concentrations can contribute to the identification of 
      subjects at higher risk for allergic rhinitis and asthma, sensitization to 
      inhalant allergens is not related to impaired spirometric lung parameters within 
      the different allergic respiratory disease subgroups.
CI  - Copyright (c) 2015 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Luzak, Agnes
AU  - Luzak A
AD  - Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center 
      for Environmental Health, Neuherberg, Germany.
FAU - Flexeder, Claudia
AU  - Flexeder C
AD  - Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center 
      for Environmental Health, Neuherberg, Germany.
FAU - von Berg, Andrea
AU  - von Berg A
AD  - Research Institute, Department of Pediatrics, Marien-Hospital Wesel, Wesel, 
      Germany.
FAU - Berdel, Dietrich
AU  - Berdel D
AD  - Research Institute, Department of Pediatrics, Marien-Hospital Wesel, Wesel, 
      Germany.
FAU - Klumper, Claudia
AU  - Klumper C
AD  - IUF Leibniz Research Institute for Environmental Medicine and Medical Faculty, 
      Heinrich Heine University of Dusseldorf, Dusseldorf, Germany.
FAU - Koletzko, Sibylle
AU  - Koletzko S
AD  - Dr von Hauner Children's Hospital, Ludwig Maximilians University of Munich, 
      Munich, Germany.
FAU - Bauer, Carl-Peter
AU  - Bauer CP
AD  - Department of Pediatrics, Technical University of Munich, Munich, Germany.
FAU - Heinrich, Joachim
AU  - Heinrich J
AD  - Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center 
      for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center 
      Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.
FAU - Nowak, Dennis
AU  - Nowak D
AD  - Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for 
      Lung Research, Munich, Germany; Institute and Outpatient Clinic for Occupational, 
      Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, 
      Germany.
FAU - Schulz, Holger
AU  - Schulz H
AD  - Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center 
      for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center 
      Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany. 
      Electronic address: schulz@helmholtz-muenchen.de.
LA  - eng
PT  - Journal Article
DEP - 20150717
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Asthma/epidemiology/*immunology
MH  - Cohort Studies
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Germany/epidemiology
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Inhalation Exposure
MH  - Lung/*physiology
MH  - Male
MH  - Maximal Midexpiratory Flow Rate/physiology
MH  - Rhinitis, Allergic/epidemiology/*immunology
MH  - Vital Capacity/physiology
EDAT- 2015/07/22 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/07/22 06:00
PHST- 2015/03/19 00:00 [received]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/22 06:00 [entrez]
PHST- 2015/07/22 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - S1081-1206(15)00407-X [pii]
AID - 10.1016/j.anai.2015.06.016 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2015 Sep;115(3):183-90. doi: 
      10.1016/j.anai.2015.06.016. Epub 2015 Jul 17.