PMID- 26196066 OWN - NLM STAT- MEDLINE DCOM- 20160802 LR - 20151008 IS - 1360-0567 (Electronic) IS - 0963-8237 (Linking) VI - 24 IP - 4 DP - 2015 Aug TI - Aerobic capacity is associated with global functioning in people with schizophrenia. PG - 214-8 LID - 10.3109/09638237.2015.1036974 [doi] AB - BACKGROUND: Although antipsychotic medications help manage clinical symptom severity, most people with schizophrenia continue to function poorly in the community. OBJECTIVE: To determine whether the Global Assessment of Functioning (GAF) score is associated with aerobic capacity in people with schizophrenia. METHOD: Thirty-four male (34.1 +/- 12.0 years) and 16 female (33.1 +/- 8.7 years) persons with schizophrenia performed the Astrand-Rhyming cycle ergometer test in order to estimate the maximal oxygen uptake (VO2max) and were assessed with the GAF, the Psychosis Evaluation tool for Common use by Caregivers and the International Physical Activity Questionnaire. RESULTS: The mean GAF-score was 41.9 +/- 9.4, while the mean estimated VO2max was 34.5 +/- 8.7mlO2/min/kg. There was a moderate association between the GAF-score and VO2max (r = 0.45, p < 0.001). Positive, negative and cognitive symptoms were negatively (p < 0.05) associated with the GAF-score, physical activity participation positively (p < 0.05). A backward regression analysis demonstrated that VO2max explained 19.1% of the GAF-score variance. CONCLUSION: In people with schizophrenia, the aerobic capacity is associated with a person's global functioning. Clinicians should consider incorporating assessment of aerobic capacity into their test battery in order to measure the health consequences of schizophrenia and its treatment. FAU - Vancampfort, Davy AU - Vancampfort D AD - a Department of Rehabilitation Sciences , KU Leuven , Leuven , Belgium . AD - b Department of Neurosciences , UPC KU Leuven, Campus Kortenberg , Korteberg , Belgium . FAU - Guelinckx, Hannes AU - Guelinckx H AD - b Department of Neurosciences , UPC KU Leuven, Campus Kortenberg , Korteberg , Belgium . FAU - Probst, Michel AU - Probst M AD - a Department of Rehabilitation Sciences , KU Leuven , Leuven , Belgium . AD - b Department of Neurosciences , UPC KU Leuven, Campus Kortenberg , Korteberg , Belgium . FAU - Ward, Philip B AU - Ward PB AD - c School of Psychiatry, University of New South Wales , Sydney , Australia . AD - d Schizophrenia Research Unit , South Western Sydney Local Health District , Liverpool , Australia . FAU - Rosenbaum, Simon AU - Rosenbaum S AD - c School of Psychiatry, University of New South Wales , Sydney , Australia . AD - e Early Psychosis Programme, The Bondi Centre, South Eastern Sydney Local Health District , Llandaff St Bondi Junction , Australia . AD - f Musculoskeletal Division , The George Institute for Global Health and School of Public Health, University of Sydney , Sydney , Australia , and. FAU - Stubbs, Brendon AU - Stubbs B AD - g School of Health and Social Care, University of Greenwich , Eltham , London , UK. FAU - De Hert, Marc AU - De Hert M AD - a Department of Rehabilitation Sciences , KU Leuven , Leuven , Belgium . LA - eng PT - Journal Article DEP - 20150721 PL - England TA - J Ment Health JT - Journal of mental health (Abingdon, England) JID - 9212352 SB - IM MH - *Activities of Daily Living/psychology MH - Adult MH - Aerobiosis/physiology MH - Exercise Test MH - Female MH - Humans MH - Male MH - Middle Aged MH - Motor Activity/physiology MH - Oxygen Consumption MH - Physical Fitness MH - Psychiatric Status Rating Scales MH - Schizophrenia/*physiopathology MH - Schizophrenic Psychology MH - Surveys and Questionnaires MH - Young Adult OTO - NOTNLM OT - Global assessment of functioning OT - physical fitness OT - psychosis EDAT- 2015/07/22 06:00 MHDA- 2016/08/03 06:00 CRDT- 2015/07/22 06:00 PHST- 2015/07/22 06:00 [entrez] PHST- 2015/07/22 06:00 [pubmed] PHST- 2016/08/03 06:00 [medline] AID - 10.3109/09638237.2015.1036974 [doi] PST - ppublish SO - J Ment Health. 2015 Aug;24(4):214-8. doi: 10.3109/09638237.2015.1036974. Epub 2015 Jul 21.