PMID- 26198953
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20211203
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 35
IP  - 7
DP  - 2015 Jul
TI  - [Association between polymorphisms in pigment epithelium-derived factor gene 
      promoter region and non-alcoholic fatty liver disease in type 2 diabetes 
      mellitus].
PG  - 1019-23
AB  - OBJECTIVE: To investigate the association of serum pigment epithelium-derived 
      factor (PEDF) level and polymorphisms in PEDF gene promoter region -358G-->A with 
      non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes 
      mellitus (T2DM) of Han Nationality in Fujian Province. METHODS: A total of 282 
      T2DM patients with NAFLD (DM1 group) and 170 age- and gender-matched T2DM 
      patients without NAFLD (DM2 group) were examined for PEDF gene SNP-358G-->A 
      polymorphisms using polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP). Serum pigment epithelium-derived factor(PEDF) level, 
      fasting plasma glucose (FPG), fasting insulin (FINS) and glycosylated hemoglobin 
      (HbA1c) were also measured. RESULTS: The patients in DM1 group showed a 
      significantly higher mean level of serum PEDF than those in DM2 group (P<0.05). 
      Logistic regression analysis revealed that PEDF level was an independent risk 
      factor for NAFLD in T2DM. The frequencies of PEDF gene -358G-->A genotypes (GG, GA, 
      and AA) and alleles (G/A) differed significanly between DM1 and DM2 groups 
      (P<0.05). In terms of PEDF gene SNP -358G-->A alleles, the GA genotype carriers had 
      a 2.032 times higher risk of developing NAFLD compared with the GG genotype 
      carriers, and the risk increased to 2.068 times in the carriers of the A allele 
      (GA and AA genotypes; P<0.05). CONCLUSION: Serum PEDF level is an independent 
      risk factor of NAFLD in T2DM. Elevated serum PEDF level is a protective factor 
      against insulin resistance. In T2DM patients, PEDF gene promoter region -358G-->A 
      polymorphism is associated with NAFLD, and the A allele contributes to an 
      increased risk of NAFLD.
FAU - Huang, Wensen
AU  - Huang W
AD  - Department of Internal Medicine, Quanzhou Medical College, Quanzhou 362000, 
      China.E-mail: vinson170@163.com.
FAU - Shi, Yaxiong
AU  - Shi Y
FAU - Yang, Xina
AU  - Yang X
FAU - Lin, Wanrong
AU  - Lin W
LA  - chi
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (pigment epithelium-derived factor)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Ethnicity
MH  - Eye Proteins/*genetics
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance
MH  - Nerve Growth Factors/*genetics
MH  - Non-alcoholic Fatty Liver Disease/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - Serpins/*genetics
EDAT- 2015/07/23 06:00
MHDA- 2015/09/26 06:00
CRDT- 2015/07/23 06:00
PHST- 2015/07/23 06:00 [entrez]
PHST- 2015/07/23 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jul;35(7):1019-23.