PMID- 26200161
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20181202
IS  - 1806-4760 (Electronic)
IS  - 0103-6440 (Linking)
VI  - 26
IP  - 3
DP  - 2015 May-Jun
TI  - Surgical treatment of bisphosphonate-related osteonecrosis of the jaws with the 
      use of buccal fat pad: case report.
PG  - 317-20
LID - S0103-64402015000300317 [pii]
LID - 10.1590/0103-6440201301918 [doi]
AB  - Bisphosphonate-related osteonecrosis of the jaws (BROJ) has been described since 
      2003 as an adverse effect of bisphosphonate medications. These drugs act on the 
      vasculature and bone remodeling, mainly on osteoclastic activity and can cause 
      areas of necrotic bone exposure. Treatment for the BROJ is not yet defined, but 
      surgical treatment is one of the forms proposed, which may cause oral deformities 
      like sinus communication in some cases. In situations like this the buccal fat 
      pad is an important alternative for coating nasal-oral communications, due its 
      large blood supply, elasticity, absence of restriction by age and safety. This 
      paper presents the case of a 58-year-old woman with BROJ in the left maxilla 
      caused by the use of zoledronic acid for metastatic breast cancer. The extensive 
      necrotic bone area was surgically removed resulting in oral sinus communication. 
      A buccal fat pad was used to cover the defect. More studies should be performed 
      regarding the treatment of BROJ but, if necessary, a buccal fat pad flap could be 
      an alternative to solve nasal-oral communications related to BROJ.
FAU - Duarte, Luiz Fernando Mathias
AU  - Duarte LF
AD  - Department of Stomatology, Universidade Paulista, Sao Paulo, SP, Brasil.
FAU - Alonso, Kleber
AU  - Alonso K
AD  - Department of Stomatology, Universidade Paulista, Sao Paulo, SP, Brasil.
FAU - Basso, Elaine Cristina
AU  - Basso EC
AD  - Department of Stomatology, Universidade Paulista, Sao Paulo, SP, Brasil.
FAU - Dib, Luciano Lauria
AU  - Dib LL
AD  - Department of Stomatology, Universidade Paulista, Sao Paulo, SP, Brasil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz Dent J
JT  - Brazilian dental journal
JID - 9214652
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Diphosphonates)
RN  - 0 (Imidazoles)
RN  - 6XC1PAD3KF (Zoledronic Acid)
MH  - Bisphosphonate-Associated Osteonecrosis of the Jaw/*surgery
MH  - Bone Density Conservation Agents/adverse effects
MH  - Diphosphonates/adverse effects
MH  - Female
MH  - Humans
MH  - Imidazoles/adverse effects
MH  - Middle Aged
MH  - Surgical Flaps
MH  - Zoledronic Acid
EDAT- 2015/07/23 06:00
MHDA- 2017/01/10 06:00
CRDT- 2015/07/23 06:00
PHST- 2013/12/14 00:00 [received]
PHST- 2015/03/23 00:00 [accepted]
PHST- 2015/07/23 06:00 [entrez]
PHST- 2015/07/23 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - S0103-64402015000300317 [pii]
AID - 10.1590/0103-6440201301918 [doi]
PST - ppublish
SO  - Braz Dent J. 2015 May-Jun;26(3):317-20. doi: 10.1590/0103-6440201301918.