PMID- 26200444
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20181202
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 218
DP  - 2015 Nov
TI  - Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic 
      intermittent hypoxia: Involving TLR4 and its downstream signaling pathway.
PG  - 57-63
LID - S1569-9048(15)30019-7 [pii]
LID - 10.1016/j.resp.2015.07.006 [doi]
AB  - Hippocampal neuronal damage is critical for the initiation and progression of 
      neurocognitive impairment accompanied obstructive sleep apnea syndrome (OSAS). 
      Toll-like receptor 4 (TLR4) plays an important role in the development of several 
      hippocampus-related neural disorders. Atorvastatin was reported beneficially 
      regulates TLR4. Here, we examined the effects of atorvastatin on hippocampal 
      injury caused by chronic intermittent hypoxia (CIH), the most characteristic 
      pathophysiological change of OSAS. Mice were exposed to intermittent hypoxia with 
      or without atorvastatin for 4 weeks. Cell damage, the expressions of TLR4 and its 
      two downstream factors myeloid differentiation factor 88 (MYD88) and 
      TIR-domain-containing adapter-inducing interferon-beta (TRIF), inflammatory agents 
      (tumor necrosis factor alpha and interleukin 1beta), and the oxidative stress 
      (superoxide dismutase and malondialdehyde) were determined. Atorvastatin 
      decreased the neural injury and the elevation of TLR4, MyD88, TRIF, 
      pro-inflammatory cytokines and oxidative stress caused by CIH. Our study suggests 
      that atorvastatin may attenuate CIH induced hippocampal neuronal damage partially 
      via TLR4 and its downstream signaling pathway.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Deng, Yan
AU  - Deng Y
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, No.1095 Jiefang Ave, Wuhan 430030, China.
FAU - Yuan, Xiao
AU  - Yuan X
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, No.1095 Jiefang Ave, Wuhan 430030, China.
FAU - Guo, Xue-ling
AU  - Guo XL
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, No.1095 Jiefang Ave, Wuhan 430030, China.
FAU - Zhu, Die
AU  - Zhu D
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, No.1095 Jiefang Ave, Wuhan 430030, China.
FAU - Pan, Yue-ying
AU  - Pan YY
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, No.1095 Jiefang Ave, Wuhan 430030, China.
FAU - Liu, Hui-guo
AU  - Liu HG
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, No.1095 Jiefang Ave, Wuhan 430030, China. 
      Electronic address: hgliu@tjh.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150719
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
RN  - 0 (IL1B protein, mouse)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - A0JWA85V8F (Atorvastatin)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Atorvastatin/*pharmacology
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Hippocampus/*drug effects/pathology/physiopathology
MH  - Hypoxia/drug therapy/pathology/physiopathology
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Mice, Inbred C57BL
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - Neurons/*drug effects/pathology/physiology
MH  - Neuroprotective Agents/*pharmacology
MH  - Random Allocation
MH  - Signal Transduction/drug effects
MH  - Sleep Apnea, Obstructive/*drug therapy/pathology/physiopathology
MH  - Superoxide Dismutase/metabolism
MH  - Toll-Like Receptor 4/*metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Atorvastatin
OT  - Hippocampus
OT  - Intermittent hypoxia
OT  - Neuroinflammation
OT  - Sleep apnea
OT  - Toll-like receptor 4
EDAT- 2015/07/23 06:00
MHDA- 2016/07/14 06:00
CRDT- 2015/07/23 06:00
PHST- 2015/04/07 00:00 [received]
PHST- 2015/07/16 00:00 [revised]
PHST- 2015/07/16 00:00 [accepted]
PHST- 2015/07/23 06:00 [entrez]
PHST- 2015/07/23 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
AID - S1569-9048(15)30019-7 [pii]
AID - 10.1016/j.resp.2015.07.006 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2015 Nov;218:57-63. doi: 10.1016/j.resp.2015.07.006. 
      Epub 2015 Jul 19.