PMID- 26200503
OWN - NLM
STAT- MEDLINE
DCOM- 20151013
LR  - 20220316
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 8
DP  - 2015 Jul
TI  - Visual Prognosis of Eyes Recovering From Macular Hole Surgery Through Automated 
      Quantitative Analysis of Spectral-Domain Optical Coherence Tomography (SD-OCT) 
      Scans.
PG  - 4631-43
LID - 10.1167/iovs.14-16344 [doi]
AB  - PURPOSE: To determine the value of topographic spectral-domain optical coherence 
      tomography (SD-OCT) imaging features assessed after macular hole repair surgery 
      in predicting visual acuity (VA) outcomes. METHODS: An automated algorithm was 
      developed to topographically outline and quantify area, extent, and location of 
      defects in the ellipsoid zone (EZ) band and inner retina layers in SD-OCT scans. 
      We analyzed the correlation of these values with VA in longitudinal observations 
      from 35 patients who underwent successful macular hole surgery, in their first 
      observation after surgery (within 2 months), and in a single observation within 6 
      to 12 months after surgery. Image features assessed at the first visit after 
      surgery were also investigated as possible predictors of future VA improvement. 
      RESULTS: Significant correlation with longitudinal VA was found for the extent, 
      circularity, and ratio of defects in EZ band at the fovea and parafoveal regions. 
      The ratio of defects in EZ band at the fovea, temporal-inner, and inferior-inner 
      macula regions showed significant strong correlation with VA within 6 to 12 
      months post surgery. Patients with worse vision outcome at such time also had a 
      significantly higher rate of inner retinal defects in the superior-outer region 
      in their first postsurgery observation. CONCLUSIONS: A lowering extent of EZ band 
      defects in the foveal and parafoveal regions is a good indicator of postsurgery 
      VA recovery. Attention should also be given to postsurgical alterations in the 
      inner retina, as patients with more extensive atrophic changes appear to have 
      slower or worse VA recovery despite closure of the macular hole.
FAU - de Sisternes, Luis
AU  - de Sisternes L
AD  - Department of Radiology Stanford University, Stanford, California, United States.
FAU - Hu, Julia
AU  - Hu J
AD  - Department of Radiology Stanford University, Stanford, California, United States 
      2Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo 
      Alto, California, United States.
FAU - Rubin, Daniel L
AU  - Rubin DL
AD  - Department of Radiology Stanford University, Stanford, California, United States 
      3Department of Medicine (Biomedical Informatics), Stanford University, Stanford, 
      California, United States.
FAU - Leng, Theodore
AU  - Leng T
AD  - Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo 
      Alto, California, United States.
LA  - eng
GR  - UL1 TR001085/TR/NCATS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Follow-Up Studies
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Postoperative Period
MH  - Prognosis
MH  - *Recovery of Function
MH  - Retinal Perforations/diagnosis/physiopathology/*surgery
MH  - Retrospective Studies
MH  - Time Factors
MH  - Tomography, Optical Coherence/methods
MH  - *Visual Acuity
MH  - Vitrectomy/*methods
PMC - PMC4515949
EDAT- 2015/07/23 06:00
MHDA- 2015/10/16 06:00
PMCR- 2016/01/01
CRDT- 2015/07/23 06:00
PHST- 2015/07/23 06:00 [entrez]
PHST- 2015/07/23 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 2398233 [pii]
AID - IOVS-14-16344 [pii]
AID - 10.1167/iovs.14-16344 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4631-43. doi: 10.1167/iovs.14-16344.