PMID- 26200742
OWN - NLM
STAT- MEDLINE
DCOM- 20160407
LR  - 20220408
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Print)
IS  - 1057-0829 (Linking)
VI  - 24
IP  - 9
DP  - 2015 Dec
TI  - Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence 
      Tomography Devices for Anterior Chamber Angle Measurements.
PG  - 642-6
LID - 10.1097/IJG.0000000000000303 [doi]
AB  - PURPOSE: To compare anterior chamber angle parameters based on the location of 
      Schwalbe line (SL) from 2 spectral domain optical coherence tomography (SD-OCT) 
      instruments and to measure their reproducibility. METHODS: Forty-two eyes from 21 
      normal, healthy participants underwent imaging of the inferior irido-corneal 
      angle with the Spectralis and Cirrus SD-OCT under tightly controlled low-light 
      conditions. SL-angle opening distance (SL-AOD) and SL-trabecular iris space area 
      (SL-TISA) were measured by masked, certified graders at the Doheny Imaging 
      Reading Center using customized grading software. Interinstrument and 
      intrainstrument, as well as interobserver and intraobserver reproducibility of 
      SL-AOD and SL-TISA measurements were evaluated by intraclass correlation 
      coefficients (ICCs) and Bland-Altman plots with limits of agreement (LoA). 
      RESULTS: The mean SL-AOD was 0.662+/-0.191 mm in Spectralis and 0.677+/-0.213 mm in 
      Cirrus. The mean SL-TISA was 0.250+/-0.073 mm in Spectralis and 0.256+/-0.082 mm in 
      Cirrus. The agreement for intrainstrument (ICCs>0.979), intragrader (ICCs>0.992), 
      and intergrader (ICCs>0.929) was excellent. Excellent agreement between the 2 
      devices was also documented with a mean difference of -0.016 (LoA -0.125 to 
      0.092) mm for SL-AOD and -0.007 (LoA -0.056 to 0.043) mm in SL-TISA. CONCLUSIONS: 
      Both SD-OCTs provided comparable measurements and permitted calculation of 
      SL-based angle metrics. There was excellent interinstrument and intrainstrument 
      and intraobserver and interobserver reproducibility for Spectralis and Cirrus 
      SD-OCTs, suggesting true interchangeability between SD-OCT devices. This has the 
      potential to lead to development of standardized grading assessments and 
      quantification of angle parameters that would be valid across various SD-OCT 
      devices.
FAU - Marion, Kenneth M
AU  - Marion KM
AD  - *Doheny Image Reading Center, Doheny Eye Institute double daggerDepartment of Ophthalmology, 
      David Geffen School of Medicine, University of California Los Angeles, Los 
      Angeles, CA daggerThe Affiliated Hospital of Medical College, Qingdao University 
      Qingdao, Shandong, P.R. China.
FAU - Maram, Jyotsna
AU  - Maram J
FAU - Pan, Xiaojing
AU  - Pan X
FAU - Dastiridou, Anna
AU  - Dastiridou A
FAU - Zhang, ZhouYuan
AU  - Zhang Z
FAU - Ho, Alex
AU  - Ho A
FAU - Francis, Brian A
AU  - Francis BA
FAU - Sadda, Srinivas R
AU  - Sadda SR
FAU - Chopra, Vikas
AU  - Chopra V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adult
MH  - Anterior Chamber/*anatomy & histology
MH  - Ciliary Body/*anatomy & histology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Iris/*anatomy & histology
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/*instrumentation
MH  - Trabecular Meshwork/anatomy & histology
PMC - PMC4667752
COIS- Disclosure: The authors declare no conflict of interest.
EDAT- 2015/07/23 06:00
MHDA- 2016/04/08 06:00
PMCR- 2015/12/02
CRDT- 2015/07/23 06:00
PHST- 2015/07/23 06:00 [entrez]
PHST- 2015/07/23 06:00 [pubmed]
PHST- 2016/04/08 06:00 [medline]
PHST- 2015/12/02 00:00 [pmc-release]
AID - 10.1097/IJG.0000000000000303 [doi]
PST - ppublish
SO  - J Glaucoma. 2015 Dec;24(9):642-6. doi: 10.1097/IJG.0000000000000303.