PMID- 2620188
OWN - NLM
STAT- MEDLINE
DCOM- 19900326
LR  - 20161018
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 22
IP  - 6
DP  - 1989
TI  - Participation of the serotonergic system in the regulation of water and 
      electrolyte balance.
PG  - 761-3
AB  - To determine the possible participation of the serotonergic (5-HT) system in the 
      regulation of water and electrolyte balance, rats were submitted to two sessions 
      of water overloading and the 5-HT agonist MK 212 was administered 
      intracerebroventricularly (icv) in 1.0 microliters 20 min after the second 
      session. Urine volume and sodium and potassium excretion were then measured over 
      a period of 120 min. Microinjection of MK-212 (1 micrograms/animal) caused a 
      significant reduction (24 to 57%; mean, 43%) in natriuresis throughout the 
      experimental period, and the administration of 10 micrograms/animal caused a 
      26-41% reduction (mean, 33%) in kaliuresis. At 20 micrograms/animal, MK-212 did 
      not change any of the parameters investigated. No significant change in urine 
      volume was detected after any of the treatments used.
FAU - Reis, L C
AU  - Reis LC
AD  - Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, Brasil.
FAU - Ramalho, M J
AU  - Ramalho MJ
FAU - Antunes-Rodrigues, J
AU  - Antunes-Rodrigues J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Pyrazines)
RN  - 059QF0KO0R (Water)
RN  - 62C3N7238U (6-chloro-2-(1-piperazinyl)pyrazine)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Injections, Intraventricular
MH  - Microinjections
MH  - Potassium/urine
MH  - Pyrazines/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sodium/urine
MH  - Water
MH  - Water-Electrolyte Balance/*drug effects
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - Braz J Med Biol Res. 1989;22(6):761-3.