PMID- 26202536
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20170223
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 74
IP  - 2
DP  - 2016
TI  - The role of baseline indirect inflammatory markers in prediction of response to 
      cardiac resynchronisation therapy.
PG  - 119-26
LID - 10.5603/KP.a2015.0142 [doi]
AB  - BACKGROUND: In many cardiovascular diseases (CVD), white blood cell counts with 
      differentials are used to predict adverse events. Both platelet-to-lymphocyte 
      ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are studied in various CVDs. 
      AIM: The role of inflammatory condition assessed using routine laboratory tests 
      in cardiac resynchronisation therapy (CRT) response has not been investigated 
      thoroughly. Therefore, we aimed to assess the association of NLR, PLR, and 
      relative lymphocyte count (L%) with response to CRT. METHODS: A total of 157 
      patients (76.4% male; mean age 58.7 +/- 11.8 years) who underwent CRT implantation 
      at our tertiary referral hospital were retrospectively analysed. RESULTS: Among 
      included patients, a total of 50 (31.8%) patients were defined as 
      "non-responders". Median NLR and PLR were significantly higher in the 
      non-responder group (p < 0.001), and median L% was significantly lower in the 
      non-responder group (p < 0.001). Also, median NLR was significantly higher in 
      patients with New York heart Association (NYHA) class II-III when compared to 
      patients with NYHA class I after six months of CRT implantation (p < 0.001, p = 
      0.004, respectively). Correlation analysis demonstrated a positive correlation 
      between paced QRS duration and NLR (p = 0.031) and a negative correlation between 
      paced QRS duration and L% (p = 0.002). In addition, both NLR and L% showed 
      significant correlations with post-procedural NYHA functional classes (p < 0.001; 
      p = 0.008, respectively). Patients with PLR > 173.09 had a 2.9‑fold and NLR > 
      3.45 had a 12.2-fold increased risk of CRT nonresponse, respectively. 
      CONCLUSIONS: In the current study non-responders to CRT had higher NLR and PLR 
      and lower L%, which may support the deleterious effects of baseline inflammatory 
      condition in advanced heart failure.
FAU - Balci, Kevser G
AU  - Balci KG
AD  - Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. 
      kevs84@gmail.com.
FAU - Balci, Mustafa M
AU  - Balci MM
FAU - Sen, Fatih
AU  - Sen F
FAU - Canpolat, Ugur
AU  - Canpolat U
FAU - Akboga, Mehmet Kadri
AU  - Akboga MK
FAU - Unal, Sefa
AU  - Unal S
FAU - Kara, Meryem
AU  - Kara M
FAU - Maden, Orhan
AU  - Maden O
FAU - Selcuk, Hatice
AU  - Selcuk H
FAU - Selcuk, Timur
AU  - Selcuk T
LA  - eng
PT  - Journal Article
DEP - 20150723
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Blood Cell Count
MH  - *Cardiac Resynchronization Therapy
MH  - Female
MH  - Heart Diseases/*therapy
MH  - Humans
MH  - *Inflammation
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - cardiac resynchronisation therapy
OT  - heart failure
OT  - lymphocyte
OT  - neutrophil
OT  - platelet
EDAT- 2015/07/24 06:00
MHDA- 2017/02/24 06:00
CRDT- 2015/07/24 06:00
PHST- 2015/03/21 00:00 [received]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/04/26 00:00 [revised]
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - VM/OJS/KP/9729 [pii]
AID - 10.5603/KP.a2015.0142 [doi]
PST - ppublish
SO  - Kardiol Pol. 2016;74(2):119-26. doi: 10.5603/KP.a2015.0142. Epub 2015 Jul 23.