PMID- 26202576
OWN - NLM
STAT- MEDLINE
DCOM- 20160623
LR  - 20221207
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 60
IP  - 11
DP  - 2015 Nov
TI  - Distribution of HLA haplotypes across Japanese Archipelago: similarity, 
      difference and admixture.
PG  - 683-90
LID - 10.1038/jhg.2015.90 [doi]
AB  - The human leukocyte antigen (HLA) region is the most polymorphic region in the 
      human genome. The polymorphic nature of the HLA region is thought to have been 
      shaped from balancing selection. The complex migration events during the 
      Out-of-Africa expansion have influenced geographic patterns of HLA allele 
      frequencies and diversities across present-day human populations. Differences in 
      the HLA allele frequency may contribute geographic differences in the 
      susceptibility to many diseases, such as infectious, autoimmune and metabolic 
      diseases. Here we briefly reviewed characteristics of frequency distribution of 
      HLA alleles and haplotypes in Japanese population. A large part of HLA alleles 
      and haplotypes that are common in Japanese are shared with neighboring Asian 
      populations. The differentiations in HLA alleles and haplotypes across Japanese 
      regional populations may provide clues to model for peopling of Japanese 
      Archipelago and for design of genetic association studies. Finally, we introduce 
      recent topics that new HLA alleles derived from ancient admixtures with 
      Neanderthals and Denisovans are thought to have played an important role in the 
      adaptation of modern humans to local pathogens during Out-of-Africa expansion.
FAU - Nakaoka, Hirofumi
AU  - Nakaoka H
AD  - Division of Human Genetics, Department of Integrated Genetics, National Institute 
      of Genetics, Shizuoka, Japan.
FAU - Inoue, Ituro
AU  - Inoue I
AD  - Division of Human Genetics, Department of Integrated Genetics, National Institute 
      of Genetics, Shizuoka, Japan.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150723
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Asian People/*genetics
MH  - Evolution, Molecular
MH  - Gene Frequency
MH  - Genetics, Population
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - History, Ancient
MH  - Hominidae/genetics/immunology
MH  - Human Migration/history
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium
MH  - Models, Genetic
MH  - Neanderthals/genetics/immunology
EDAT- 2015/07/24 06:00
MHDA- 2016/06/24 06:00
CRDT- 2015/07/24 06:00
PHST- 2015/06/02 00:00 [received]
PHST- 2015/06/19 00:00 [revised]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2016/06/24 06:00 [medline]
AID - jhg201590 [pii]
AID - 10.1038/jhg.2015.90 [doi]
PST - ppublish
SO  - J Hum Genet. 2015 Nov;60(11):683-90. doi: 10.1038/jhg.2015.90. Epub 2015 Jul 23.