PMID- 26202804
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20150812
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 86
IP  - 3
DP  - 2015 Sep
TI  - Meta-analysis of the human leukocyte antigen-G (HLA-G) 14 bp insertion/deletion 
      polymorphism as a risk factor for preeclampsia.
PG  - 186-94
LID - 10.1111/tan.12627 [doi]
AB  - The non-classical major histocompatibility complex, human leukocyte antigen 
      (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction 
      between maternal immune cells and fetal trophoblasts invading the uterine wall, 
      to ensure successful placental development and function. Several HLA-G gene 
      variants have been shown to be associated with development of preeclampsia (PE), 
      but the reported associations of the HLA-G 14 base pair (bp) insertion/deletion 
      (I/D) polymorphism (rs66554220) with PE are inconsistent. In this meta-analysis 
      of HLA-G 14 bp I/D in each member of the family triad, we estimated risk (odds 
      ratio [OR], 95% confidence interval) of associations with PE based on nine 
      published offspring, nine mother and three father case-control studies. No 
      significant increased risk associations between PE and HLA-G 14 bp I/D were 
      detected in any of the family triad members (offspring: OR = 1.08-1.21, P = 
      0.57-0.74; mothers: OR = 1.11-1.28, P = 0.07-0.44; fathers: OR = 1.09-1.65, P = 
      0.07-0.70). Of the 20 comparisons performed, 14 (70%) were non-heterogeneous and 
      seven of these had zero heterogeneity (I(2) = 0%). Sensitivity treatment 
      confirmed robustness for the overall lack of association for HLA-G 14 bp I/D. In 
      subgroup analysis, significant association between HLA-G 14 bp I/D and PE was 
      shown in offspring from primipara (OR = 1.66-1.95, P = 0.04) and European 
      Caucasian pregnancies (OR = 1.37-2.03, P = 0.02-0.03). However, heterogeneity and 
      sensitivity tests suggest that further investigation is needed to determine if 
      HLA-G 14 bp I/D is involved in trophoblast HLA-G expression and PE development in 
      these subgroups.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Pabalan, N
AU  - Pabalan N
AUID- ORCID: 0000-0003-2069-5535
AD  - Center for Research and Development, Angeles University Foundation, Angeles City, 
      2009, Philippines.
AD  - School of Medicine, Saint Louis University, Baguio City, 2600, Philippines.
FAU - Jarjanazi, H
AU  - Jarjanazi H
AD  - Environmental Monitoring and Reporting Branch, Biomonitoring Unit, Ontario 
      Ministry of the Environment and Climate Change, Ontario, M9P 3V6, Canada.
FAU - Sun, C
AU  - Sun C
AD  - Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, 
      N-5021, Norway.
FAU - Iversen, A C
AU  - Iversen AC
AD  - Centre of Molecular Inflammation Research, and Department of Cancer Research and 
      Molecular Medicine, Norwegian University of Science and Technology, Trondheim, 
      N-7491, Norway.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150722
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - *Base Pairing
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Heterogeneity
MH  - *Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics
MH  - Homozygote
MH  - Humans
MH  - INDEL Mutation/*genetics
MH  - *Polymorphism, Genetic
MH  - Pre-Eclampsia/*genetics
MH  - Pregnancy
MH  - Risk Factors
OTO - NOTNLM
OT  - human leukocyte antigen-G
OT  - meta-analysis
OT  - polymorphism
OT  - preeclampsia
EDAT- 2015/07/24 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/07/24 06:00
PHST- 2015/02/14 00:00 [received]
PHST- 2015/06/04 00:00 [revised]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - 10.1111/tan.12627 [doi]
PST - ppublish
SO  - Tissue Antigens. 2015 Sep;86(3):186-94. doi: 10.1111/tan.12627. Epub 2015 Jul 22.