PMID- 26202808
OWN - NLM
STAT- MEDLINE
DCOM- 20160719
LR  - 20220410
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 28
IP  - 1
DP  - 2015 Sep
TI  - Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-kappaB 
      and MAPK signaling pathways in LPS-induced mastitis in mice.
PG  - 470-6
LID - S1567-5769(15)30025-4 [pii]
LID - 10.1016/j.intimp.2015.07.012 [doi]
AB  - Baicalein is a phenolic flavonoid presented in the dry roots of Scutellaria 
      baicalensis Georgi. It has been reported that baicalein possesses a number of 
      biological properties, such as antiviral, antioxidative, anti-inflammatory, 
      antithrombotic, and anticancer properties. However, the effect of baicalein on 
      mastitis has not yet been reported. This research aims to detect the effect of 
      baicalein on lipopolysaccharide (LPS)-induced mastitis in mice and to investigate 
      the molecular mechanisms. Baicalein was administered intraperitoneally 1h before 
      and 12h after LPS treatment. The results indicated that baicalein treatment 
      markedly attenuated the damage of the mammary gland induced by LPS, suppressed 
      the activity of myeloperoxidase (MPO) and the levels of tumor necrosis factor 
      (TNF-alpha) and interleukin (IL-1beta) in mice with LPS-induced mastitis. Besides, 
      baicalein blocked the expression of Toll-like receptor 4 (TLR4) and then 
      suppressed the phosphorylation of nuclear transcription factor-kappaB (NF-kappaB) p65 
      and degradation inhibitor of NF-kappaBalpha (IkappaBalpha) and, and inhibited the phosphorylation 
      of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase 
      (JNK) in mitogen-activated protein kinase (MAPK) signal pathway. These findings 
      suggested that baicalein may have a potential prospect against mastitis.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - He, Xuexiu
AU  - He X
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China.
FAU - Wei, Zhengkai
AU  - Wei Z
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China.
FAU - Zhou, Ershun
AU  - Zhou E
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China.
FAU - Chen, Libin
AU  - Chen L
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China.
FAU - Kou, Jinhua
AU  - Kou J
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China.
FAU - Wang, Jingjing
AU  - Wang J
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China.
FAU - Yang, Zhengtao
AU  - Yang Z
AD  - College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, 
      People's Republic of China. Electronic address: yangzhengtao01@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150718
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Flavanones)
RN  - 0 (IL1B protein, mouse)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 49QAH60606 (baicalein)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/*therapeutic use
MH  - Female
MH  - Flavanones/*pharmacology/*therapeutic use
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides
MH  - MAP Kinase Signaling System/drug effects
MH  - Male
MH  - Mammary Glands, Animal/drug effects/pathology
MH  - Mastitis/chemically induced/*drug therapy/*metabolism/pathology
MH  - Mice, Inbred BALB C
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Peroxidase/metabolism
MH  - Signal Transduction/drug effects
MH  - Toll-Like Receptor 4/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Baicalein
OT  - Lipopolysaccharide
OT  - MAPKs
OT  - Mastitis
OT  - NF-kappaB
OT  - TLR4
EDAT- 2015/07/24 06:00
MHDA- 2016/07/20 06:00
CRDT- 2015/07/24 06:00
PHST- 2015/01/23 00:00 [received]
PHST- 2015/07/10 00:00 [revised]
PHST- 2015/07/10 00:00 [accepted]
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2016/07/20 06:00 [medline]
AID - S1567-5769(15)30025-4 [pii]
AID - 10.1016/j.intimp.2015.07.012 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2015 Sep;28(1):470-6. doi: 10.1016/j.intimp.2015.07.012. 
      Epub 2015 Jul 18.