PMID- 26203065
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20220409
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Print)
IS  - 1522-8517 (Linking)
VI  - 17
IP  - 12
DP  - 2015 Dec
TI  - Screening for cognitive deficits in 8 to 14-year old children with cerebellar 
      tumors using self-report measures of executive and behavioral functioning and 
      health-related quality of life.
PG  - 1628-36
LID - 10.1093/neuonc/nov129 [doi]
AB  - BACKGROUND: We aimed to identify a brief screening measure for detection of 
      cognitive deficit in children treated for cerebellar tumors that would be useful 
      in clinical practice. METHODS: A sample of 72 children, aged 8-14 years, and 
      within 3 years post diagnosis for standard-risk medulloblastoma (n = 37) or 
      low-grade cerebellar astrocytoma (n = 35) and 38 children in a nontumor group 
      were assessed using teacher-, parent-, and child-report of the Behavior Rating 
      Inventory of Executive Function (BRIEF), Strengths and Difficulties Questionnaire 
      (SDQ), and Pediatric Quality of Life Inventory (PedsQL). The accuracy of these 
      scores as a screen for a full-scale Intelligence Quotient (FSIQ) < 80 on the 
      Wechsler Intelligence Scale for Children (WISC-IV UK) was assessed using their 
      receiver operating characteristic (ROC) curves. RESULTS: The questionnaires with 
      the highest areas under the ROC curves were the child- and parent-report PedsQL, 
      the teacher-report BRIEF, and the SDQ. At optimal cutoff scores, their 
      sensitivities (95% CIs) to cases of FSIQ < 80 were 84 (60-96)%, 65 (41-84)%, 79 
      (54-93)%, and 84 (60-96)%, and their specificities (95% CIs) were 79 (68-86)%, 87 
      (77-93)%, 77 (66-86)%, and 71 (64-84)% respectively. All cases of FSIQ < 80 
      screened positive on either teacher-report SDQ or self-report PedsQL. 
      CONCLUSIONS: The PedsQL child- and parent-report and the teacher-report BRIEF and 
      SDQ have moderately good accuracy for discriminating between children with and 
      without a FSIQ < 80. The PedsQL could be used in a clinical setting, and the 
      BRIEF and SDQ in an educational setting, to screen for cases with FSIQ < 80 in 
      children treated for brain tumors.
CI  - (c) The Author(s) 2015. Published by Oxford University Press on behalf of the 
      Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Bull, Kim S
AU  - Bull KS
AD  - Faculty of Medicine, University of Southampton, Southampton General Hospital, 
      Southampton, UK (K.S.B., H.M.Y, C.R.K.); University Hospital Southampton NHS 
      Foundation Trust, Southampton, UK (C.R.K.); School of Psychology, Faculty of 
      Social and Human Sciences, University of Southampton, Southampton, UK (C.L.); 
      Division of Health and Social Care Research, King's College London, London, UK 
      (J.L.P.); NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation 
      Trust, London, UK (J.L.P.).
FAU - Liossi, Christina
AU  - Liossi C
AD  - Faculty of Medicine, University of Southampton, Southampton General Hospital, 
      Southampton, UK (K.S.B., H.M.Y, C.R.K.); University Hospital Southampton NHS 
      Foundation Trust, Southampton, UK (C.R.K.); School of Psychology, Faculty of 
      Social and Human Sciences, University of Southampton, Southampton, UK (C.L.); 
      Division of Health and Social Care Research, King's College London, London, UK 
      (J.L.P.); NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation 
      Trust, London, UK (J.L.P.).
FAU - Peacock, Janet L
AU  - Peacock JL
AD  - Faculty of Medicine, University of Southampton, Southampton General Hospital, 
      Southampton, UK (K.S.B., H.M.Y, C.R.K.); University Hospital Southampton NHS 
      Foundation Trust, Southampton, UK (C.R.K.); School of Psychology, Faculty of 
      Social and Human Sciences, University of Southampton, Southampton, UK (C.L.); 
      Division of Health and Social Care Research, King's College London, London, UK 
      (J.L.P.); NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation 
      Trust, London, UK (J.L.P.).
FAU - Yuen, Ho Ming
AU  - Yuen HM
AD  - Faculty of Medicine, University of Southampton, Southampton General Hospital, 
      Southampton, UK (K.S.B., H.M.Y, C.R.K.); University Hospital Southampton NHS 
      Foundation Trust, Southampton, UK (C.R.K.); School of Psychology, Faculty of 
      Social and Human Sciences, University of Southampton, Southampton, UK (C.L.); 
      Division of Health and Social Care Research, King's College London, London, UK 
      (J.L.P.); NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation 
      Trust, London, UK (J.L.P.).
FAU - Kennedy, Colin R
AU  - Kennedy CR
AD  - Faculty of Medicine, University of Southampton, Southampton General Hospital, 
      Southampton, UK (K.S.B., H.M.Y, C.R.K.); University Hospital Southampton NHS 
      Foundation Trust, Southampton, UK (C.R.K.); School of Psychology, Faculty of 
      Social and Human Sciences, University of Southampton, Southampton, UK (C.L.); 
      Division of Health and Social Care Research, King's College London, London, UK 
      (J.L.P.); NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation 
      Trust, London, UK (J.L.P.).
CN  - Children's Cancer and Leukaemia Group (CCLG)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150722
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
SB  - IM
MH  - Adolescent
MH  - Astrocytoma/*complications
MH  - Cerebellar Neoplasms/*complications
MH  - Child
MH  - Cognition Disorders/*diagnosis/etiology
MH  - *Executive Function
MH  - Female
MH  - Humans
MH  - Intelligence Tests
MH  - Longitudinal Studies
MH  - Male
MH  - Medulloblastoma/*complications
MH  - Prospective Studies
MH  - *Quality of Life
MH  - ROC Curve
MH  - *Self Report
MH  - Sensitivity and Specificity
PMC - PMC4633931
OTO - NOTNLM
OT  - cerebellar tumors
OT  - children
OT  - cognitive deficit
OT  - health-related quality of life
OT  - screening
EDAT- 2015/07/24 06:00
MHDA- 2016/08/23 06:00
PMCR- 2016/12/01
CRDT- 2015/07/24 06:00
PHST- 2015/04/21 00:00 [received]
PHST- 2015/06/12 00:00 [accepted]
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - nov129 [pii]
AID - 10.1093/neuonc/nov129 [doi]
PST - ppublish
SO  - Neuro Oncol. 2015 Dec;17(12):1628-36. doi: 10.1093/neuonc/nov129. Epub 2015 Jul 
      22.