PMID- 26203182
OWN - NLM
STAT- MEDLINE
DCOM- 20160802
LR  - 20151022
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Linking)
VI  - 70
IP  - 11
DP  - 2015 Nov
TI  - Pulmonary drug delivery: a review on nanocarriers for antibacterial chemotherapy.
PG  - 2945-55
LID - 10.1093/jac/dkv192 [doi]
AB  - As the WHO stated, lower respiratory infections are the third leading cause of 
      death. In addition, it is remarkable that antimicrobial resistance represents a 
      huge threat. Thus, new therapeutic weapons are required. Among the possible 
      alternatives, antibiotic encapsulation in nanoparticles has gained much attention 
      in terms of improved tolerability, activity and ability to combat the resistance 
      mechanisms of bacteria. In this regard, this review article focuses on the latest 
      nanocarrier approaches for inhalatory therapy of antibiotics. First, the 
      technology related to lung disposition will be reviewed. Then, nanocarrier 
      systems will be introduced and the challenges required to perform adequate 
      pulmonary deposition analysed. In the following part, drug delivery systems 
      (DDSs) on the market or in clinical trials are described and, finally, new 
      approaches of nanoparticles that have reached pre-clinical stage are enumerated. 
      Altogether, this review aims at gathering together the novel nanosystems for 
      anti-infectious therapy, underlining the potential of DDSs to improve and 
      optimize currently available antibiotic therapies in the context of lung 
      infections.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of the British 
      Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Moreno-Sastre, M
AU  - Moreno-Sastre M
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, 
      Spain Biomedical Research Networking Center in Bioengineering, Biomaterials and 
      Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain.
FAU - Pastor, M
AU  - Pastor M
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, 
      Spain Biomedical Research Networking Center in Bioengineering, Biomaterials and 
      Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain.
FAU - Salomon, C J
AU  - Salomon CJ
AD  - Laboratory of Pharmaceutical Technology, Biochemical and Pharmaceutical Sciences 
      Faculty, National University of Rosario, Suipacha 531, 2000 Rosario, Argentina 
      Rosario Chemistry Institute, IQUIR-CONICET, Suipacha 531, 2000 Rosario, 
      Argentina.
FAU - Esquisabel, A
AU  - Esquisabel A
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, 
      Spain Biomedical Research Networking Center in Bioengineering, Biomaterials and 
      Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain.
FAU - Pedraz, J L
AU  - Pedraz JL
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, 
      Spain Biomedical Research Networking Center in Bioengineering, Biomaterials and 
      Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain joseluis.pedraz@ehu.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150722
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Administration, Inhalation
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Bacterial Infections/*drug therapy
MH  - Drug Carriers/*administration & dosage
MH  - Drug Therapy/methods
MH  - Humans
MH  - Nanoparticles/*administration & dosage
MH  - Respiratory Tract Infections/*drug therapy
EDAT- 2015/07/24 06:00
MHDA- 2016/08/03 06:00
CRDT- 2015/07/24 06:00
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2016/08/03 06:00 [medline]
AID - dkv192 [pii]
AID - 10.1093/jac/dkv192 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2015 Nov;70(11):2945-55. doi: 10.1093/jac/dkv192. Epub 
      2015 Jul 22.