PMID- 26204310
OWN - NLM
STAT- MEDLINE
DCOM- 20151007
LR  - 20150724
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 205
IP  - 2
DP  - 2015 Aug
TI  - Quantitative Skeletal Muscle MRI: Part 2, MR Spectroscopy and T2 Relaxation Time 
      Mapping-Comparison Between Boys With Duchenne Muscular Dystrophy and Healthy 
      Boys.
PG  - W216-23
LID - 10.2214/AJR.14.13755 [doi]
AB  - OBJECTIVE: The purpose of this study is to validate the use of MR spectroscopy 
      (MRS) in measuring muscular fat and to compare it with T2 maps in differentiating 
      boys with Duchenne muscular dystrophy (DMD) from healthy boys. SUBJECTS AND 
      METHODS: Forty-two boys with DMD and 31 healthy boys were evaluated with MRI with 
      (1)H-MRS and T2 maps. Grading of muscle fat and edema on conventional images, 
      calculation of fat fractions ([fat / fat] + water) on MRS, and calculation of T2 
      fat values on T2 maps of the gluteus maximus and vastus lateralis muscles were 
      performed. Group comparisons were made. The 95% reference interval (RI) of fat 
      fraction for the control group was applied and compared with T2 map results. 
      RESULTS: Minimal fat on T1-weighted images was seen in 90.3% (gluteus maximus) 
      and 71.0% (vastus lateralis) of healthy boys, versus 33.3% (gluteus maximus) and 
      52.4% (vastus lateralis) of boys with DMD. Muscle edema was seen in none of the 
      healthy boys versus 52.4% (gluteus maximus) and 57.1% (vastus lateralis) of the 
      boys with DMD. Fat fractions were higher in the DMD group (52.7%, gluteus 
      maximus; 27.3%, vastus lateralis) than in the control group (12.8%, gluteus 
      maximus; 13.7%, vastus lateralis) (p < 0.001). The 95% RI for gluteus maximus 
      (38.7%) resulted in 61.9% sensitivity and 100% specificity for differentiating 
      boys with DMD from healthy boys, whereas the value for vastus lateralis (17.8%) 
      resulted in 76.2% sensitivity and 100% specificity; both had lower accuracy than 
      did T2 maps (100% sensitivity and specificity). There was a positive correlation 
      between T2 fat values and fat fractions (p < 0.0001). CONCLUSION: In 
      differentiation of the two groups, T2 maps were more accurate than MRS. Fat 
      fractions can underestimate the actual amount of fat because of coexisting muscle 
      edema in DMD.
FAU - Kim, Hee Kyung
AU  - Kim HK
AD  - 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 
      Burnet Ave, Cincinnati, OH 45229-3039.
FAU - Serai, Suraj
AU  - Serai S
AD  - 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 
      Burnet Ave, Cincinnati, OH 45229-3039.
FAU - Lindquist, Diana
AU  - Lindquist D
AD  - 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 
      Burnet Ave, Cincinnati, OH 45229-3039.
FAU - Merrow, Arnold C
AU  - Merrow AC
AD  - 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 
      Burnet Ave, Cincinnati, OH 45229-3039.
FAU - Horn, Paul S
AU  - Horn PS
AD  - 2 Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH.
AD  - 3 Department of Neurology, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, OH.
FAU - Kim, Dong Hoon
AU  - Kim DH
AD  - 4 Department of Pharmacology, Korea University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Wong, Brenda L
AU  - Wong BL
AD  - 3 Department of Neurology, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, OH.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Muscle, Skeletal/*pathology
MH  - Muscular Dystrophy, Duchenne/*pathology
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Duchenne muscular dystrophy
OT  - MR spectroscopy
OT  - MRI
OT  - T2 relaxation time mapping
OT  - skeletal muscle
EDAT- 2015/07/24 06:00
MHDA- 2015/10/08 06:00
CRDT- 2015/07/24 06:00
PHST- 2015/07/24 06:00 [entrez]
PHST- 2015/07/24 06:00 [pubmed]
PHST- 2015/10/08 06:00 [medline]
AID - 10.2214/AJR.14.13755 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2015 Aug;205(2):W216-23. doi: 10.2214/AJR.14.13755.