PMID- 26204833 OWN - NLM STAT- MEDLINE DCOM- 20160421 LR - 20220309 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 16 IP - 7 DP - 2015 Jul 20 TI - Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population. PG - 16483-96 LID - 10.3390/ijms160716483 [doi] AB - Oxidative stress is a major risk factor in the onset and progression of type 2 diabetes mellitus (T2DM). NF-E2 related factor 2 (NRF2) is a pivotal transcription factor in oxidative stress related illnesses. This study included 2174 subjects with 879 cases of newly-diagnosed T2DM and 1295 healthy controls. Compared to individuals with the CC genotype, those with the AA genotype had lower total anti-oxidative capacity, superoxide dismutase, catalase, glutathione, glutathione peroxidase activity; and lower homeostasis model assessment of beta-cell function index. Those with the AA genotype also had a higher malondialdehyde concentration and homeostasis model assessment of insulin resistance index values. The frequency of allele A was significantly higher in T2DM subjects (29.4%), compared to control subjects (26.1%; p = 0.019). Individuals with the AA genotype had a significantly higher risk of developing T2DM (OR 1.56; 95% CI 1.11, 2.20; p = 0.011), relative to those with the CC genotype, even after adjusting for known T2DM risk factors. Our results suggest that the NRF2 rs6721961 polymorphism was significantly associated with oxidative stress, anti-oxidative status, and risk of newly-diagnosed T2DM. This polymorphism may also contribute to impaired insulin secretory capacity and increased insulin resistance in a Chinese population. FAU - Wang, Xia AU - Wang X AD - Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China. wangxiaes@sdu.edu.cn. AD - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. wangxiaes@sdu.edu.cn. FAU - Chen, Hongxia AU - Chen H AD - Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China. hustchenhx@163.com. FAU - Liu, Jun AU - Liu J AD - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. liujunxju@sina.com. FAU - Ouyang, Yingying AU - Ouyang Y AD - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. xiongying0217@gmail.com. FAU - Wang, Di AU - Wang D AD - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. wad1983@126.com. FAU - Bao, Wei AU - Bao W AD - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. baowei0613@gmail.com. FAU - Liu, Liegang AU - Liu L AD - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. lgliu@mails.tjmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150720 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (NF-E2-Related Factor 2) RN - 0 (NFE2L2 protein, human) RN - EC 1.11.1.6 (Catalase) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - EC 1.15.1.1 (Superoxide Dismutase) RN - GAN16C9B8O (Glutathione) SB - IM MH - Adult MH - Aged MH - Case-Control Studies MH - Catalase/blood MH - China MH - Diabetes Mellitus, Type 2/blood/*genetics/metabolism MH - Female MH - Glutathione/blood MH - Glutathione Peroxidase/blood MH - Humans MH - Male MH - Middle Aged MH - NF-E2-Related Factor 2/*genetics MH - Oxidative Stress MH - *Polymorphism, Single Nucleotide MH - Superoxide Dismutase/blood PMC - PMC4519961 OTO - NOTNLM OT - NRF2 OT - oxidative stress OT - polymorphism OT - type 2 diabetes EDAT- 2015/07/25 06:00 MHDA- 2016/04/22 06:00 PMCR- 2015/07/01 CRDT- 2015/07/25 06:00 PHST- 2015/03/21 00:00 [received] PHST- 2015/06/14 00:00 [revised] PHST- 2015/06/30 00:00 [accepted] PHST- 2015/07/25 06:00 [entrez] PHST- 2015/07/25 06:00 [pubmed] PHST- 2016/04/22 06:00 [medline] PHST- 2015/07/01 00:00 [pmc-release] AID - ijms160716483 [pii] AID - ijms-16-16483 [pii] AID - 10.3390/ijms160716483 [doi] PST - epublish SO - Int J Mol Sci. 2015 Jul 20;16(7):16483-96. doi: 10.3390/ijms160716483.