PMID- 26205380
OWN - NLM
STAT- MEDLINE
DCOM- 20160817
LR  - 20191210
IS  - 1432-2099 (Electronic)
IS  - 0301-634X (Linking)
VI  - 54
IP  - 4
DP  - 2015 Nov
TI  - Analysis of EPR and FISH studies of radiation doses in persons who lived in the 
      upper reaches of the Techa River.
PG  - 433-44
LID - 10.1007/s00411-015-0611-8 [doi]
AB  - Waterborne radioactive releases into the Techa River from the Mayak Production 
      Association in Russia during 1949-1956 resulted in significant doses to about 
      30,000 persons who lived in downstream settlements. The residents were exposed to 
      internal and external radiation. Two methods for reconstruction of the external 
      dose are considered in this paper, electron paramagnetic resonance (EPR) 
      measurements of teeth, and fluorescence in situ hybridization (FISH) measurements 
      of chromosome translocations in circulating lymphocytes. The main issue in the 
      application of the EPR and FISH methods for reconstruction of the external dose 
      for the Techa Riverside residents was strontium radioisotopes incorporated in 
      teeth and bones that act as a source of confounding local exposures. In order to 
      estimate and subtract doses from incorporated (89,90)Sr, the EPR and FISH assays 
      were supported by measurements of (90)Sr-body burdens and estimates of (90)Sr 
      concentrations in dental tissues by the luminescence method. The resulting dose 
      estimates derived from EPR to FISH measurements for residents of the upper Techa 
      River were found to be consistent: The mean values vary from 510 to 550 mGy for 
      the villages located close to the site of radioactive release to 130-160 mGy for 
      the more distant villages. The upper bound of individual estimates for both 
      methods is equal to 2.2-2.3 Gy. The EPR- and FISH-based dose estimates were 
      compared with the doses calculated for the donors using the most recent Techa 
      River Dosimetry System (TRDS). The TRDS external dose assessments are based on 
      the data on contamination of the Techa River floodplain, simulation of air kerma 
      above the contaminated soil, age-dependent lifestyles and individual residence 
      histories. For correct comparison, TRDS-based doses were calculated from two 
      sources: external exposure from the contaminated environment and internal 
      exposure from (137)Cs incorporated in donors' soft tissues. It is shown here that 
      the TRDS-based absorbed doses in tooth enamel and muscle are in agreement with 
      EPR- and FISH-based estimates within uncertainty bounds. Basically, this 
      agreement between the estimates has confirmed the validity of external doses 
      calculated with the TRDS.
FAU - Degteva, M O
AU  - Degteva MO
AD  - Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, 
      Russian Federation, 454076. marina@urcrm.ru.
FAU - Shagina, N B
AU  - Shagina NB
AD  - Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, 
      Russian Federation, 454076.
FAU - Shishkina, E A
AU  - Shishkina EA
AD  - Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, 
      Russian Federation, 454076. lena@urcrm.ru.
FAU - Vozilova, A V
AU  - Vozilova AV
AD  - Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, 
      Russian Federation, 454076.
FAU - Volchkova, A Y
AU  - Volchkova AY
AD  - Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, 
      Russian Federation, 454076.
FAU - Vorobiova, M I
AU  - Vorobiova MI
AD  - Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, 
      Russian Federation, 454076.
FAU - Wieser, A
AU  - Wieser A
AD  - Helmholtz Centrum Munich, Neuherberg, Germany.
FAU - Fattibene, P
AU  - Fattibene P
AD  - Instituto Superiore di Sanita, Rome, Italy.
FAU - Della Monaca, S
AU  - Della Monaca S
AD  - Instituto Superiore di Sanita, Rome, Italy.
FAU - Ainsbury, E
AU  - Ainsbury E
AD  - Public Health England, Chilton, Didcot, UK.
FAU - Moquet, J
AU  - Moquet J
AD  - Public Health England, Chilton, Didcot, UK.
FAU - Anspaugh, L R
AU  - Anspaugh LR
AD  - University of Utah, Salt Lake City, UT, USA.
FAU - Napier, B A
AU  - Napier BA
AD  - Pacific Northwest National Laboratory, Richland, WA, USA.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150724
PL  - Germany
TA  - Radiat Environ Biophys
JT  - Radiation and environmental biophysics
JID - 0415677
RN  - 0 (Radioactive Waste)
RN  - 0 (Strontium Radioisotopes)
RN  - 0 (Water Pollutants, Radioactive)
SB  - IM
MH  - Absorption, Radiation
MH  - Aged
MH  - Aged, 80 and over
MH  - Biological Assay
MH  - Dental Enamel/*chemistry
MH  - *Electron Spin Resonance Spectroscopy
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Muscle, Skeletal/*chemistry
MH  - Radiation Exposure/*analysis
MH  - *Radiation Monitoring
MH  - Radioactive Hazard Release
MH  - Radioactive Waste/analysis
MH  - Reproducibility of Results
MH  - Russia
MH  - Sensitivity and Specificity
MH  - Strontium Radioisotopes/*analysis
MH  - Water Pollutants, Radioactive/analysis
MH  - Whole-Body Counting
OTO - NOTNLM
OT  - Dose reconstruction
OT  - Electron paramagnetic resonance
OT  - Environmental contamination
OT  - Fluorescence in situ hybridization
OT  - Techa River
EDAT- 2015/07/25 06:00
MHDA- 2016/08/18 06:00
CRDT- 2015/07/25 06:00
PHST- 2015/04/01 00:00 [received]
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/07/25 06:00 [entrez]
PHST- 2015/07/25 06:00 [pubmed]
PHST- 2016/08/18 06:00 [medline]
AID - 10.1007/s00411-015-0611-8 [pii]
AID - 10.1007/s00411-015-0611-8 [doi]
PST - ppublish
SO  - Radiat Environ Biophys. 2015 Nov;54(4):433-44. doi: 10.1007/s00411-015-0611-8. 
      Epub 2015 Jul 24.