PMID- 26205534
OWN - NLM
STAT- MEDLINE
DCOM- 20160929
LR  - 20221207
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 36
IP  - 12
DP  - 2015 Dec
TI  - The diagnostic and prognostic value of serum CXCL12 levels in patients with 
      ischemic stroke.
PG  - 2227-34
LID - 10.1007/s10072-015-2341-8 [doi]
AB  - The aim of this study was to investigate the potential diagnostic and prognostic 
      role of CXC chemokine ligand-12 (CXCL12) in Chinese patients with acute ischemic 
      stroke (AIS). All consecutive patients with first-ever AIS from January 2014 to 
      August 2014 were recruited to participate in the study. CXCL12 and NIH Stroke 
      Scale were measured at the time of admission. Short-term functional outcome was 
      measured by modified Rankin scale 3 months after admission. Multivariate analyses 
      were performed using logistic regression models. Receiver operating 
      characteristic (ROC) curve was used to evaluate the accuracy of serum CXCL12 in 
      diagnosing stroke and prognosing functional outcome. From 375 screened patients, 
      a total of 288 patients with first-ever AIS were included in this study. Based on 
      the ROC curve, the optimal cutoff value of serum CXCL12 levels as an indicator 
      for auxiliary diagnosis of AIS was projected to be 3.5 ng/mL, which yielded a 
      sensitivity of 88.1 % and a specificity of 73.5 %, with the area under the curve 
      at 0.907 (95 % CI 0.882-0.932). In multivariate analysis, there was an increased 
      risk of unfavorable outcome associated with serum CXCL12 levels >/=7.6 ng/mL (OR 
      4.356, 95 % CI 2.993-7.132, P < 0.0001) after adjusting for possible confounders. 
      Our study demonstrated that elevated serum CXCL12 level at admission was an 
      independent diagnostic and prognostic marker in patients with AIS.
FAU - Duan, Xiao-Xia
AU  - Duan XX
AD  - Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, 
      No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of 
      China. sunxy452@126.com.
FAU - Zhang, Guan-Peng
AU  - Zhang GP
AD  - Department of Electrocardiogram, The Affiliated Hospital of Luzhou Medical 
      College, Luzhou, 646000, People's Republic of China.
FAU - Wang, Xiao-Bin
AU  - Wang XB
AD  - Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, 
      No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of 
      China.
FAU - Yu, Hua
AU  - Yu H
AD  - Department of Electrocardiogram, The Affiliated Hospital of Luzhou Medical 
      College, Luzhou, 646000, People's Republic of China.
FAU - Wu, Jia-Li
AU  - Wu JL
AD  - Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, 
      No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of 
      China.
FAU - Liu, Ke-Zhi
AU  - Liu KZ
AD  - Department of Psychiatry, The Affiliated Hospital of Luzhou Medical College, 
      Luzhou, 646000, People's Republic of China.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Psychiatry, The Affiliated Hospital of Luzhou Medical College, 
      Luzhou, 646000, People's Republic of China.
FAU - Long, Xiang
AU  - Long X
AD  - Department of Anesthesiology, The Affiliated Hospital of Luzhou Medical College, 
      No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150724
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/diagnosis
MH  - Chemokine CXCL12/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Stroke/*blood/*diagnosis
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - CXC chemokine ligand-12
OT  - Chinese
OT  - Diagnosis
OT  - Marker
OT  - Prognostic
EDAT- 2015/07/25 06:00
MHDA- 2016/09/30 06:00
CRDT- 2015/07/25 06:00
PHST- 2015/02/17 00:00 [received]
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/07/25 06:00 [entrez]
PHST- 2015/07/25 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
AID - 10.1007/s10072-015-2341-8 [pii]
AID - 10.1007/s10072-015-2341-8 [doi]
PST - ppublish
SO  - Neurol Sci. 2015 Dec;36(12):2227-34. doi: 10.1007/s10072-015-2341-8. Epub 2015 
      Jul 24.