PMID- 26206599
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20181113
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 31
IP  - 4
DP  - 2015 Aug
TI  - Chaperone-mediated autophagy: roles in neuroprotection.
PG  - 452-8
LID - 10.1007/s12264-015-1540-x [doi]
AB  - Chaperone-mediated autophagy (CMA), one of the main pathways of lysosomal 
      proteolysis, is characterized by the selective targeting and direct translocation 
      into the lysosomal lumen of substrate proteins containing a targeting motif 
      biochemically related to the pentapeptide KFERQ. Along with the other two 
      lysosomal pathways, macro- and micro-autophagy, CMA is essential for maintaining 
      cellular homeostasis and survival by selectively degrading misfolded, oxidized, 
      or damaged cytosolic proteins. CMA plays an important role in pathologies such as 
      cancer, kidney disorders, and neurodegenerative diseases. Neurons are 
      post-mitotic and highly susceptible to dysfunction of cellular quality-control 
      systems. Maintaining a balance between protein synthesis and degradation is 
      critical for neuronal functions and homeostasis. Recent studies have revealed 
      several new mechanisms by which CMA protects neurons through regulating factors 
      critical for their viability and homeostasis. In the current review, we summarize 
      recent advances in the understanding of the regulation and physiology of CMA with 
      a specific focus on its possible roles in neuroprotection.
FAU - Cai, Zhibiao
AU  - Cai Z
AD  - Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, 710038, China.
FAU - Zeng, Weijun
AU  - Zeng W
FAU - Tao, Kai
AU  - Tao K
FAU - E, Zhen
AU  - E Z
FAU - Wang, Bao
AU  - Wang B
FAU - Yang, Qian
AU  - Yang Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150723
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Molecular Chaperones)
SB  - IM
MH  - Alzheimer Disease/metabolism
MH  - Animals
MH  - Autophagy/*physiology
MH  - Humans
MH  - Huntington Disease/metabolism
MH  - Lysosomes/metabolism/*physiology
MH  - Molecular Chaperones/metabolism/physiology
MH  - Neurons/metabolism/*physiology
MH  - Parkinson Disease/metabolism
PMC - PMC5563711
EDAT- 2015/07/25 06:00
MHDA- 2016/05/03 06:00
PMCR- 2016/08/01
CRDT- 2015/07/25 06:00
PHST- 2015/05/04 00:00 [received]
PHST- 2015/06/23 00:00 [accepted]
PHST- 2015/07/25 06:00 [entrez]
PHST- 2015/07/25 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 1540 [pii]
AID - 10.1007/s12264-015-1540-x [doi]
PST - ppublish
SO  - Neurosci Bull. 2015 Aug;31(4):452-8. doi: 10.1007/s12264-015-1540-x. Epub 2015 
      Jul 23.