PMID- 26207261
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2352-8729 (Print)
IS  - 2352-8729 (Electronic)
IS  - 2352-8729 (Linking)
VI  - 1
IP  - 2
DP  - 2015 Jun 1
TI  - Plasma BDNF levels associate with Pittsburgh compound B binding in the brain.
PG  - 187-193
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in 
      Alzheimer's disease (AD) and other neurodegenerative disorders. BDNF function is 
      adversely affected by amyloid beta (Abeta) in AD. BDNF levels in brain and 
      peripheral tissues are lower in patients with AD and MCI, than in controls. Here 
      we examined the association between plasma levels of BDNF and amyloid deposition 
      in the brain measured with Pittsburgh Compound B (PiB). METHOD: Our dataset 
      consisted of 18 AD, 56 mild cognitive impairment (MCI) and 3 normal control (NC) 
      Alzheimer's Disease Neuroimaging Initiative-1 (ADNI1) subjects with available 
      [(11)C] PiB and peripheral blood protein data. MRI-coregistered PET data was 
      smoothed with a 15 mm kernel and mapped onto 3D hemispheric models using the 
      warping deformations computed in cortical pattern matching of the associated MRI 
      scans. We applied linear regression to examine in 3D the associations between 
      BDNF and PiB SUVR, while adjusting for age and sex. We used permutation 
      statistics thresholded at p<0.01 for multiple comparisons correction. RESULTS: 
      Plasma BDNF levels showed significant negative associations with left greater 
      than right amyloid burden in the lateral temporal, inferior parietal, inferior 
      frontal, anterior and posterior cingulate, and orbitofrontal regions (left 
      p(corrected)=0.03). CONCLUSIONS: As hypothesized, lower plasma levels of BDNF 
      were significantly associated with widespread brain amyloidosis.
FAU - Hwang, Kristy S
AU  - Hwang KS
AD  - Oakland University William Beaumont School of Medicine, Rochester Hills, MI USA.
FAU - Lazaris, Andreas S
AU  - Lazaris AS
AD  - University of California Berkeley, Berkeley, CA, USA.
FAU - Eastman, Jennifer A
AU  - Eastman JA
AD  - Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
FAU - Teng, Edmond
AU  - Teng E
AD  - Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 
      USA ; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 
      USA.
FAU - Thompson, Paul M
AU  - Thompson PM
AD  - Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA.
FAU - Gylys, Karen H
AU  - Gylys KH
AD  - School of Nursing, UCLA, CA, USA.
FAU - Cole, Gregory M
AU  - Cole GM
AD  - Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 
      USA ; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 
      USA.
FAU - Apostolova, Liana G
AU  - Apostolova LG
AD  - Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 
      USA ; Mary S. Easton Center for Alzheimer's Disease Research, UCLA, Los Angeles, 
      CA, USA.
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
GR  - K02 AG048240/AG/NIA NIH HHS/United States
GR  - P50 AG016570/AG/NIA NIH HHS/United States
GR  - R01 AG040770/AG/NIA NIH HHS/United States
GR  - U01 AG024904/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Alzheimers Dement (Amst)
JT  - Alzheimer's & dementia (Amsterdam, Netherlands)
JID - 101654604
PMC - PMC4507280
MID - NIHMS696774
EDAT- 2015/07/25 06:00
MHDA- 2015/07/25 06:01
PMCR- 2015/04/22
CRDT- 2015/07/25 06:00
PHST- 2015/07/25 06:00 [entrez]
PHST- 2015/07/25 06:00 [pubmed]
PHST- 2015/07/25 06:01 [medline]
PHST- 2015/04/22 00:00 [pmc-release]
AID - S2352-8729(15)00039-1 [pii]
AID - 10.1016/j.dadm.2015.01.005 [doi]
PST - ppublish
SO  - Alzheimers Dement (Amst). 2015 Jun 1;1(2):187-193. doi: 
      10.1016/j.dadm.2015.01.005.