PMID- 26207618
OWN - NLM
STAT- MEDLINE
DCOM- 20160919
LR  - 20211203
IS  - 2291-2797 (Electronic)
IS  - 2291-2789 (Print)
IS  - 2291-2789 (Linking)
VI  - 29
IP  - 8
DP  - 2015 Nov-Dec
TI  - Prevalence of celiac disease and celiac autoimmunity in the Toba Native 
      Amerindian community of Argentina.
PG  - 431-4
LID - 16817 [pii]
AB  - BACKGROUND: Celiac disease (CD) is mostly recognized among subjects with a 
      Caucasian ethnic ancestry. No studies have explored conditions predisposing 
      Amerindians to CD. OBJECTIVE: To prospectively assess environmental, genetic and 
      serological conditions associated with CD among members of the Toba native 
      population attending a multidisciplinary sanitary mission. METHODS: An expert 
      nutritionist determined daily gluten intake using an established questionnaire. 
      Gene typing for the human leukocyte antigen (HLA) class II alleles was performed 
      on DNA extracted from peripheral blood (HLA DQ2⁄DQ8 haplotype). Serum antibodies 
      were immunoglobulin (Ig) A tissue transglutaminase (tTG) and the composite 
      deamidated gliadin peptides⁄tTG Screen test. Positive cases were tested for IgA 
      endomysial antibodies. RESULTS: A total of 144 subjects (55% female) were 
      screened. The estimated mean gluten consumption was 43 g⁄day (range 3 g⁄day to 
      185 g⁄day). Genetic typing showed that 73 of 144 (50.7%) subjects had alleles 
      associated with CD; 69 (94.5%) of these subjects had alleles for HLA DQ8 and four 
      had DQ2 (5.5%). Four and six subjects had antibody concentrations above the 
      cut-off established by the authors' laboratory (>3 times the upper limit of 
      normal) for IgA tTG and deamidated gliadin peptides⁄tTG screen, respectively. 
      Four of these had concomitant positivity for both assays and endomysial 
      antibodies were positive in three subjects who also presented a predisposing 
      haplotype. CONCLUSION: The present study was the first to detect CD in 
      Amerindians. The native Toba ethnic population has very high daily gluten 
      consumption and a predisposing genetic background. We detected subjects with 
      persistent CD autoimmunity and, at least, three of them fulfilled serological 
      criteria for CD diagnosis.
FAU - Vazquez, Horacio
AU  - Vazquez H
FAU - de la Paz Temprano, Maria
AU  - de la Paz Temprano M
FAU - Sugai, Emilia
AU  - Sugai E
FAU - Scacchi, Stella M
AU  - Scacchi SM
FAU - Souza, Cecilia
AU  - Souza C
FAU - Cisterna, Daniel
AU  - Cisterna D
FAU - Smecuol, Edgardo
AU  - Smecuol E
FAU - Moreno, Maria Laura
AU  - Moreno ML
FAU - Longarini, Gabriela
AU  - Longarini G
FAU - Mazure, Roberto
AU  - Mazure R
FAU - Bartellini, Maria A
AU  - Bartellini MA
FAU - Verdu, Elena F
AU  - Verdu EF
FAU - Gonzalez, Andrea
AU  - Gonzalez A
FAU - Maurino, Eduardo
AU  - Maurino E
FAU - Bai, Julio
AU  - Bai J
LA  - eng
GR  - MOP 123282/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150724
PL  - Egypt
TA  - Can J Gastroenterol Hepatol
JT  - Canadian journal of gastroenterology & hepatology
JID - 101623613
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (Immunoglobulin A)
RN  - 8002-80-0 (Glutens)
RN  - 9007-90-3 (Gliadin)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Argentina/epidemiology
MH  - Autoantibodies/immunology
MH  - Autoimmunity/genetics/immunology
MH  - Celiac Disease/*ethnology/genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Diet/*statistics & numerical data
MH  - Female
MH  - GTP-Binding Proteins/immunology
MH  - Gliadin/immunology
MH  - *Glutens
MH  - HLA-DQ Antigens/genetics
MH  - Humans
MH  - Immunoglobulin A/immunology
MH  - Indians, South American/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Transglutaminases/immunology
MH  - Young Adult
PMC - PMC4699604
EDAT- 2015/07/25 06:00
MHDA- 2016/09/20 06:00
PMCR- 2016/05/01
CRDT- 2015/07/25 06:00
PHST- 2015/07/25 06:00 [entrez]
PHST- 2015/07/25 06:00 [pubmed]
PHST- 2016/09/20 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - 16817 [pii]
AID - cjgh-29-431 [pii]
AID - 10.1155/2015/927458 [doi]
PST - ppublish
SO  - Can J Gastroenterol Hepatol. 2015 Nov-Dec;29(8):431-4. doi: 10.1155/2015/927458. 
      Epub 2015 Jul 24.