PMID- 2620787
OWN - NLM
STAT- MEDLINE
DCOM- 19900319
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 13
IP  - 4
DP  - 1989 Nov
TI  - Teratogenic assessment of 2,4-dichlorophenol in Fischer 344 rats.
PG  - 635-40
AB  - The potential maternal, embryotoxic, and teratogenic parameters of 
      2,4-dichlorophenol (2,4-DCP) were evaluated in Fischer 344 rats following oral 
      administration in corn oil on Days 6 through 15 of gestation. Dose levels were 0, 
      200, 375, and 750 mg/kg/day. Females were sacrificed on Gestation Day 20 and 
      cesarean sections performed. The fetuses were weighed, sexed, measured for 
      crown-rump length, and examined for external malformations. A skeletal 
      examination was conducted on one-half of the fetuses after staining with alizarin 
      red S. The remaining fetuses were fixed in Bouin's solution and examined for 
      visceral anomalies and developmental variations. Maternal body weight gain 
      inhibition occurred in all 2,4-dichlorophenol-treated groups during the treatment 
      period. Four treatment-related deaths occurred in the 750 mg/kg/day group. 
      Additional indicators of maternal toxicity included urogenital staining of the 
      fur at all levels tested, and an increased incidence of hair loss and respiratory 
      rales at the 750 mg/kg/day level. Fetal examinations did not reveal differences 
      in the incidence of external, visceral, or skeletal fetal malformations in any 
      treatment group, when compared with the control group. A slight increase in early 
      embryonic death occurred in the high-dose group only. Fetal weights were lower in 
      the high-dose group than in the control group. Variations in skeletal structure 
      were expressed among fetuses exposed to 750 mg/kg/day during organogenesis. These 
      included delayed ossification of sternal elements and vertebral arches. The 
      reduced fetal weights, intrauterine survival, and retarded ossification may 
      represent a slight degree of embryotoxicity or fetotoxicity in this group. The 
      test material was not teratogenic at any dose level.
FAU - Rodwell, D E
AU  - Rodwell DE
AD  - Department of Reproduction and Teratology, WIL Research Laboratories, Inc., 
      Ashland, Ohio 44805-9281.
FAU - Wilson, R D
AU  - Wilson RD
FAU - Nemec, M D
AU  - Nemec MD
FAU - Mercieca, M D
AU  - Mercieca MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Chlorophenols)
RN  - 0 (Teratogens)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Chlorophenols/*toxicity
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred F344
MH  - Reproduction/drug effects
MH  - *Teratogens
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1016/0272-0590(89)90321-7 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1989 Nov;13(4):635-40. doi: 10.1016/0272-0590(89)90321-7.