PMID- 26208714
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 15
DP  - 2015 Jul 25
TI  - Erosive esophageal reflux vs. non erosive esophageal reflux: oral findings in 71 
      patients.
PG  - 84
LID - 10.1186/s12903-015-0069-8 [doi]
LID - 84
AB  - BACKGROUND: The purpose of this clinical study was to assess the prevalence of 
      acidic oral mucosal lesions and periodontal conditions in patients suffering from 
      erosive esophageal reflux disease (ERD) compared with non erosive esophageal 
      reflux disease (NERD) patients, both treated with long term proton pump 
      inhibitors (PPI). METHODS: Seventy-one patients with diagnosed GERD were studied: 
      i.e. 29 ERD and 42 NERD patients. Thorough visual examination of the oral mucosa 
      and a periodontal evaluation was performed. The primary outcome was defined as a 
      statistically significant difference, between the two groups, in the presence of 
      acidic lesions of the oral mucosa and specific periodontal parameters. RESULTS: 
      This study failed to demonstrate statistically significant differences between 
      ERD and NERD patients with respect to the prevalence of oral mucosal lesions. 
      However, significantly more ERD patients suffered from severe periodontitis (CAL 
      >/= 5 mm) as compared to NERD patients. Accordingly, it may be assumed that PPI-use 
      had no adverse effects on the prevalence of acidic oral mucosal lesions and on 
      periodontal destruction. CONCLUSIONS: Within the limitations of this study it may 
      be concluded that ERD and NERD patients need separate evaluation with respect to 
      periodontal destruction. Moreover, long term PPI medication had no adverse 
      clinical impact on acidic oral mucosal lesions and periodontal destruction. 
      Further studies are necessary to elucidate the role of reflux in the periodontal 
      destruction of ERD individuals.
FAU - Deppe, Herbert
AU  - Deppe H
AD  - Department of Oral and Maxillofacial Surgery, Technical University of Munich, 
      Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany. 
      herbert.deppe@mkg.med.tum.de.
AD  - Klinik und Poliklinik fur Mund-Kiefer-Gesichtschirurgie, Technische Universitat 
      Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675, Munchen, 
      Germany. herbert.deppe@mkg.med.tum.de.
FAU - Mucke, Thomas
AU  - Mucke T
AD  - Department of Oral and Maxillofacial Surgery, Technical University of Munich, 
      Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany. 
      th.mucke@gmx.de.
FAU - Wagenpfeil, Stefan
AU  - Wagenpfeil S
AD  - Institute for Medical Biometry, Epidemiology and Medical Informatics, University 
      of Saarland, Homburg/Saar, Germany. sw@med-imbei.uni-saarland.de.
FAU - Kesting, Marco
AU  - Kesting M
AD  - Department of Oral and Maxillofacial Surgery, Technical University of Munich, 
      Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany. 
      kesting@mkg.med.tum.de.
FAU - Rozej, Anna
AU  - Rozej A
AD  - Department of Oral and Maxillofacial Surgery, Technical University of Munich, 
      Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany. 
      anna.rozej@campus.lmu.de.
FAU - Bajbouj, Monther
AU  - Bajbouj M
AD  - Department of Internal Medical Department II, Technical University of Munich, 
      Klinikum rechts der Isar, Munchen, Germany. monther.bajbouj@lrz.tum.de.
FAU - Sculean, Anton
AU  - Sculean A
AD  - Department of Periodontology, University of Berne, Bern, Switzerland. 
      anton.sculean@zmk.unibe.ch.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150725
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Ulcer Agents/therapeutic use
MH  - Dental Plaque Index
MH  - Erythema/etiology
MH  - Female
MH  - Gastric Acid
MH  - Gastroesophageal Reflux/*complications/drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/*etiology
MH  - Oral Ulcer/etiology
MH  - Periodontal Attachment Loss/etiology
MH  - Periodontal Diseases/*etiology
MH  - Periodontal Index
MH  - Periodontal Pocket/etiology
MH  - Periodontitis/etiology
MH  - Photography, Dental/methods
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Stomatitis/etiology
MH  - Tongue Diseases/etiology
MH  - Young Adult
PMC - PMC4513381
EDAT- 2015/07/26 06:00
MHDA- 2016/12/15 06:00
PMCR- 2015/07/25
CRDT- 2015/07/26 06:00
PHST- 2015/01/15 00:00 [received]
PHST- 2015/07/14 00:00 [accepted]
PHST- 2015/04/26 00:00 [revised]
PHST- 2015/07/26 06:00 [entrez]
PHST- 2015/07/26 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2015/07/25 00:00 [pmc-release]
AID - 10.1186/s12903-015-0069-8 [pii]
AID - 69 [pii]
AID - 10.1186/s12903-015-0069-8 [doi]
PST - epublish
SO  - BMC Oral Health. 2015 Jul 25;15:84. doi: 10.1186/s12903-015-0069-8.