PMID- 26208973
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20181113
IS  - 1432-1777 (Electronic)
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 26
IP  - 9-10
DP  - 2015 Oct
TI  - Principles and application of LIMS in mouse clinics.
PG  - 467-81
LID - 10.1007/s00335-015-9586-7 [doi]
AB  - Large-scale systemic mouse phenotyping, as performed by mouse clinics for more 
      than a decade, requires thousands of mice from a multitude of different mutant 
      lines to be bred, individually tracked and subjected to phenotyping procedures 
      according to a standardised schedule. All these efforts are typically organised 
      in overlapping projects, running in parallel. In terms of logistics, data 
      capture, data analysis, result visualisation and reporting, new challenges have 
      emerged from such projects. These challenges could hardly be met with traditional 
      methods such as pen & paper colony management, spreadsheet-based data management 
      and manual data analysis. Hence, different Laboratory Information Management 
      Systems (LIMS) have been developed in mouse clinics to facilitate or even enable 
      mouse and data management in the described order of magnitude. This review shows 
      that general principles of LIMS can be empirically deduced from LIMS used by 
      different mouse clinics, although these have evolved differently. Supported by 
      LIMS descriptions and lessons learned from seven mouse clinics, this review also 
      shows that the unique LIMS environment in a particular facility strongly 
      influences strategic LIMS decisions and LIMS development. As a major conclusion, 
      this review states that there is no universal LIMS for the mouse research domain 
      that fits all requirements. Still, empirically deduced general LIMS principles 
      can serve as a master decision support template, which is provided as a hands-on 
      tool for mouse research facilities looking for a LIMS.
FAU - Maier, Holger
AU  - Maier H
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany. holger.maier@helmholtz-muenchen.de.
FAU - Schutt, Christine
AU  - Schutt C
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - Steinkamp, Ralph
AU  - Steinkamp R
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - Hurt, Anja
AU  - Hurt A
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - Schneltzer, Elida
AU  - Schneltzer E
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - Gormanns, Philipp
AU  - Gormanns P
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - Lengger, Christoph
AU  - Lengger C
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - Griffiths, Mark
AU  - Griffiths M
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Melvin, David
AU  - Melvin D
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Agrawal, Neha
AU  - Agrawal N
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Alcantara, Rafael
AU  - Alcantara R
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Evans, Arthur
AU  - Evans A
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Gannon, David
AU  - Gannon D
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Holroyd, Simon
AU  - Holroyd S
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Kipp, Christian
AU  - Kipp C
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Raj, Navis Pretheeba
AU  - Raj NP
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - Richardson, David
AU  - Richardson D
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, 
      Cambridgeshire, CB10 1SA, UK.
FAU - LeBlanc, Sophie
AU  - LeBlanc S
AD  - Institut Clinique de la Souris - ICS, 1 rue Laurent Fries, BP 10142, 67404, 
      Illkirch Cedex, France.
FAU - Vasseur, Laurent
AU  - Vasseur L
AD  - Institut Clinique de la Souris - ICS, 1 rue Laurent Fries, BP 10142, 67404, 
      Illkirch Cedex, France.
FAU - Masuya, Hiroshi
AU  - Masuya H
AD  - RIKEN BioResource Center, Kouyadai 3-1-1, Ibaraki, 306-0074, Japan.
FAU - Kobayashi, Kimio
AU  - Kobayashi K
AD  - RIKEN BioResource Center, Kouyadai 3-1-1, Ibaraki, 306-0074, Japan.
FAU - Suzuki, Tomohiro
AU  - Suzuki T
AD  - RIKEN BioResource Center, Kouyadai 3-1-1, Ibaraki, 306-0074, Japan.
FAU - Tanaka, Nobuhiko
AU  - Tanaka N
AD  - RIKEN BioResource Center, Kouyadai 3-1-1, Ibaraki, 306-0074, Japan.
FAU - Wakana, Shigeharu
AU  - Wakana S
AD  - RIKEN BioResource Center, Kouyadai 3-1-1, Ibaraki, 306-0074, Japan.
FAU - Walling, Alison
AU  - Walling A
AD  - Mary Lyon Centre, Medical Research Council Harwell, Harwell Science and 
      Innovation Campus, Harwell, Oxfordshire, OX11 0RD, UK.
FAU - Clary, David
AU  - Clary D
AD  - Mouse Biology Program, University of California, Davis, 2795 2nd Street, Suite 
      400, Davis, CA, 95618, USA.
FAU - Gallegos, Juan
AU  - Gallegos J
AD  - Department of Molecular and Human Genetics, Baylor College of Medicine, One 
      Baylor Plaza, Houston, TX, 77030, USA.
FAU - Fuchs, Helmut
AU  - Fuchs H
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
FAU - de Angelis, Martin Hrabe
AU  - de Angelis MH
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany. hrabe@helmholtz-muenchen.de.
AD  - Chair for Experimental Genetics, Life and Food Science Center Weihenstephan, 
      Technische Universitat Munich, Freising-Weihenstephan, 85354, Munich, Germany. 
      hrabe@helmholtz-muenchen.de.
AD  - Member of German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. 
      hrabe@helmholtz-muenchen.de.
FAU - Gailus-Durner, Valerie
AU  - Gailus-Durner V
AD  - German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum 
      Munchen - German Research Center for Environmental Health (GmbH), Ingolstadter 
      Landstr. 1, 85764, Neuherberg, Germany.
LA  - eng
GR  - U42 OD011174/OD/NIH HHS/United States
GR  - U42 OD011175/OD/NIH HHS/United States
GR  - U54 HG006364/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150725
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
SB  - IM
MH  - Animals
MH  - *Biomedical Research
MH  - *Clinical Laboratory Information Systems
MH  - Mice
MH  - *Software
PMC - PMC4602070
EDAT- 2015/07/26 06:00
MHDA- 2016/07/07 06:00
PMCR- 2015/07/25
CRDT- 2015/07/26 06:00
PHST- 2015/05/06 00:00 [received]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2015/07/26 06:00 [entrez]
PHST- 2015/07/26 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
PHST- 2015/07/25 00:00 [pmc-release]
AID - 10.1007/s00335-015-9586-7 [pii]
AID - 9586 [pii]
AID - 10.1007/s00335-015-9586-7 [doi]
PST - ppublish
SO  - Mamm Genome. 2015 Oct;26(9-10):467-81. doi: 10.1007/s00335-015-9586-7. Epub 2015 
      Jul 25.