PMID- 26209256
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20220410
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 35
IP  - 4
DP  - 2016 Aug
TI  - Effects of beta-carotene fortified synbiotic food on metabolic control of 
      patients with type 2 diabetes mellitus: A double-blind randomized cross-over 
      controlled clinical trial.
PG  - 819-25
LID - S0261-5614(15)00186-7 [pii]
LID - 10.1016/j.clnu.2015.07.009 [doi]
AB  - BACKGROUND & AIMS: The aim of the present study was to determine the beneficial 
      effects of beta-carotene fortified synbiotic food intake on metabolic status in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: This randomized 
      double-blinded placebo-controlled crossover clinical trial was conducted among 51 
      patients with T2DM. Individuals were randomly assigned to take either a 
      beta-carotene fortified synbiotic (n = 51) or control food (n = 51) for 6 weeks. 
      The beta-carotene fortified synbiotic was containing Lactobacillus sporogenes 
      (1 x 10(7) CFU), 0.1 g inulin and 0.05 g beta-carotene. Control food (the same 
      substance without probiotic, inulin and beta-carotene) was packed in identical 
      9-g packages. Patients were requested to use the beta-carotene fortified 
      synbiotic and control foods three times a day. RESULTS: Beta-carotene fortified 
      synbiotic food consumption resulted in a significant decrease in insulin 
      (-1.00 +/- 7.90 vs. +3.68 +/- 6.91 muIU/mL, P = 0.002), HOMA-IR (-0.73 +/- 3.96 
      vs. +1.82 +/- vbnm4.09, P = 0.002), HOMA-B (-0.52 +/- 19.75 vs. +8.71 +/- 17.15, 
      P = 0.01), triglycerides (-2.86 +/- 49.53 vs. +20.14 +/- 50.10 mg/dL, P = 0.02), 
      VLDL-cholesterol levels (-0.57 +/- 9.90 vs. +4.03 +/- 10.02 mg/dL, P = 0.02) and 
      total-/HDL-cholesterol ratio (-0.01 +/- 1.08 vs. +0.64 +/- 0.81, P = 0.001) compared 
      to the control food. In addition, beta-carotene fortified synbiotic food 
      consumption led to elevated plasma nitric oxide (NO) (+6.83 +/- 16.14 vs. 
      -3.76 +/- 16.47 mumol/L, P = 0.001) and glutathione (GSH) (+36.58 +/- 296.71 vs. 
      -92.04 +/- 243.05 mumol/L, P = 0.01). CONCLUSIONS: Beta-carotene fortified synbiotic 
      food intake in patients with T2DM for 6 weeks had favorable effects on insulin, 
      HOMA-IR, HOMA-B, triglycerides, VLDL-cholesterol, total-/HDL-cholesterol ratio, 
      NO and GSH levels.
CI  - Copyright (c) 2015 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Asemi, Zatollah
AU  - Asemi Z
AD  - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan 
      University of Medical Sciences, Kashan, Iran.
FAU - Alizadeh, Sabihe-Alsadat
AU  - Alizadeh SA
AD  - Department of Research and Development of Sekkeh Gaz Company, Isfahan, Iran.
FAU - Ahmad, Khorshidi
AU  - Ahmad K
AD  - Department of Microbiology, Kashan University of Medical Sciences, Kashan, Iran.
FAU - Goli, Mohammad
AU  - Goli M
AD  - Department of Food Science and Technology, Islamic Azad University, Khorasgan 
      Branch, Khorasgan, Iran.
FAU - Esmaillzadeh, Ahmad
AU  - Esmaillzadeh A
AD  - Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 
      Iran; Department of Community Nutrition, School of Nutrition and Food Science, 
      Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: 
      Esmaillzadeh@hlth.mui.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150716
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 01YAE03M7J (beta Carotene)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9005-80-5 (Inulin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bacillus coagulans/metabolism
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cholesterol/blood
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Double-Blind Method
MH  - Female
MH  - *Food, Fortified
MH  - Glutathione/blood
MH  - Humans
MH  - Inflammation/blood/drug therapy
MH  - Insulin/blood
MH  - Inulin/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/blood
MH  - Oxidative Stress/drug effects
MH  - Synbiotics/*administration & dosage
MH  - Triglycerides/blood
MH  - beta Carotene/*administration & dosage/analysis
OTO - NOTNLM
OT  - Inflammation
OT  - Metabolic profiles
OT  - Oxidative stress
OT  - Synbiotic
OT  - Type 2 diabetes
EDAT- 2015/07/26 06:00
MHDA- 2018/01/19 06:00
CRDT- 2015/07/26 06:00
PHST- 2015/02/06 00:00 [received]
PHST- 2015/07/05 00:00 [revised]
PHST- 2015/07/06 00:00 [accepted]
PHST- 2015/07/26 06:00 [entrez]
PHST- 2015/07/26 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
AID - S0261-5614(15)00186-7 [pii]
AID - 10.1016/j.clnu.2015.07.009 [doi]
PST - ppublish
SO  - Clin Nutr. 2016 Aug;35(4):819-25. doi: 10.1016/j.clnu.2015.07.009. Epub 2015 Jul 
      16.