PMID- 26209260
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20221207
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 43
IP  - 1
DP  - 2016 Feb
TI  - Association of serum 25-hydroxyvitamin D with serum IgE levels in Korean adults.
PG  - 84-8
LID - S0385-8146(15)00168-6 [pii]
LID - 10.1016/j.anl.2015.06.010 [doi]
AB  - OBJECTIVE: Studies about the association between vitamin D and allergic disease 
      and the immune-modulatory function of vitamin D have increased in the recent 
      years. However, not enough studies have been conducted for concrete conclusion 
      about the association vitamin D and allergy. We investigate the association 
      between serum immunoglobulin E (IgE) and serum 25-hydroxyvitamin D (25(OH)D) 
      levels in Korean adults. METHODS: We used data of 1969 subjects from the 2010 
      Korean National Health and Nutrition Examination Survey. Total IgE, 
      Dermatophagoides farinae (Df)-specific IgE, and serum 25(OH)D levels were 
      analyzed. Other variables included sex, age, body mass index, smoking history, 
      and economic status. Adjusted regression analysis was used to examine the 
      independent association of 25(OH)D with serum IgE levels. RESULTS: When we 
      divided all subjects into four groups according to the serum 25(OH)D level: Q1 
      (lowest), Q2, Q3, and Q4 (highest), the median TIgE level increased with higher 
      quartiles in the Kruskal-Wallis test (p<0.001). Also, the prevalence of Df 
      sensitization was highest in Q4. Serum vitamin D was positively associated with 
      logarithmic transformed total IgE with base of 10 (LogTIgE) (coefficient (B), 
      0.011; 95% confidence interval, 0.001-0.021). Furthermore, a positive association 
      between 25(OH)D and LogTIgE was found only in men with Df sensitization, but not 
      in men without Df sensitization and women with/without Df sensitization. However, 
      the mean serum 25(OH)D level was significantly lower in participants who were 
      clinically diagnosed with asthma or atopic dermatitis than participants without a 
      history of asthma or atopic dermatitis, respectively. CONCLUSION: Serum 25(OH)D 
      levels were positively associated with total IgE levels. Furthermore, the 
      association between serum 25(OH)D and total IgE levels could vary depending on 
      sex or allergic sensitization. But, the mean serum 25(OH)D level was lower in 
      participants with asthma or atopic dermatitis history than participants without 
      history of asthma or atopic dermatitis. Prospective further studies will be 
      required to verify this discrepancy.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Kang, Ju Wan
AU  - Kang JW
AD  - Department of Otorhinolaryngology, Jeju National University School of Medicine, 
      Jeju, Republic of Korea; Department of Medicine, Yonsei University Graduate 
      School, Seoul, Republic of Korea.
FAU - Kim, Jeong Hong
AU  - Kim JH
AD  - Department of Otorhinolaryngology, Jeju National University School of Medicine, 
      Jeju, Republic of Korea.
FAU - Kim, Hyun Jik
AU  - Kim HJ
AD  - Department of Otorhinolaryngology, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Lee, Jeung-Gweon
AU  - Lee JG
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Yoon, Joo-Heon
AU  - Yoon JH
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kim, Chang-Hoon
AU  - Kim CH
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea. Electronic address: entman@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20150721
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Animals
MH  - Asian People
MH  - Asthma/*blood/epidemiology/immunology
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Dermatitis, Atopic/*blood/epidemiology/immunology
MH  - Dermatophagoides farinae/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Nutrition Surveys
MH  - Republic of Korea/epidemiology
MH  - Sex Factors
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Allergy
OT  - Dermatophagoides farinae
OT  - Immunoglobulin E
OT  - Specific IgE
OT  - Vitamin D
EDAT- 2015/07/26 06:00
MHDA- 2016/11/03 06:00
CRDT- 2015/07/26 06:00
PHST- 2015/03/04 00:00 [received]
PHST- 2015/06/23 00:00 [revised]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/07/26 06:00 [entrez]
PHST- 2015/07/26 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
AID - S0385-8146(15)00168-6 [pii]
AID - 10.1016/j.anl.2015.06.010 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2016 Feb;43(1):84-8. doi: 10.1016/j.anl.2015.06.010. Epub 
      2015 Jul 21.