PMID- 26210694
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 233
IP  - 3
DP  - 2015 Sep 30
TI  - Meta-cognition is associated with cortical thickness in youth at clinical high 
      risk of psychosis.
PG  - 418-23
LID - S0925-4927(15)30033-0 [pii]
LID - 10.1016/j.pscychresns.2015.07.010 [doi]
AB  - Meta-cognition is compromised in people with schizophrenia and people at clinical 
      high risk (CHR) of psychosis. In the current work in a CHR sample, we 
      hypothesized that meta-cognitive functions would correlate with cortical 
      thickness in five brain regions implicated in the pathogenesis of psychosis: 
      inferior and middle frontal cortices, anterior cingulate cortex, superior 
      temporal cortex and insula. Secondly, we hypothesized that similar neural systems 
      would underlie different meta-cognitive functions. Narratives were gathered for 
      29 youth at CHR of psychosis using a semi-structured interview. Four 
      meta-cognitive functions within the narratives were measured with the 
      Meta-cognition Assessment Scale and regressed on cortical thickness from our a 
      priori regions of interest using FreeSurfer. Mapping statistics from our a priori 
      regions of interest revealed that meta-cognition functions were associated with 
      cortical thickness in inferior and middle frontal gyri, superior temporal cortex 
      and insula. The distribution of cortical thickness was partially similar across 
      the four MAS items. Results confirm our hypothesis that cortical thickness is 
      significantly associated with meta-cognition in brain regions that consistently 
      show gray matter reductions across the schizophrenia spectrum. Evidence for 
      thickness covariation in a variety of regions suggests partial dependence in the 
      neural architecture underlying various meta-cognitive functions in CHR.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Buchy, Lisa
AU  - Buchy L
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. 
      Electronic address: lbuchy@ucalgary.ca.
FAU - Stowkowy, Jacque
AU  - Stowkowy J
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
FAU - MacMaster, Frank P
AU  - MacMaster FP
AD  - Department of Psychiatry and Pediatrics, University of Calgary, Calgary, Alberta, 
      Canada.
FAU - Nyman, Karissa
AU  - Nyman K
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
LA  - eng
GR  - U01MH081984/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150715
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Brain Mapping/methods
MH  - Cerebral Cortex/*pathology
MH  - Female
MH  - Frontal Lobe/pathology
MH  - Gyrus Cinguli/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - *Metacognition/physiology
MH  - Organ Size
MH  - Psychotic Disorders/*diagnosis/*psychology
MH  - Risk Factors
MH  - Temporal Lobe/pathology
OTO - NOTNLM
OT  - Clinical high risk
OT  - Cortical thickness
OT  - Meta-cognition
OT  - Prefrontal cortex
OT  - Schizophrenia
OT  - Self-reflectiveness
EDAT- 2015/07/27 06:00
MHDA- 2016/04/09 06:00
CRDT- 2015/07/27 06:00
PHST- 2014/07/29 00:00 [received]
PHST- 2015/05/22 00:00 [revised]
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/07/27 06:00 [entrez]
PHST- 2015/07/27 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
AID - S0925-4927(15)30033-0 [pii]
AID - 10.1016/j.pscychresns.2015.07.010 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Sep 30;233(3):418-23. doi: 
      10.1016/j.pscychresns.2015.07.010. Epub 2015 Jul 15.