PMID- 26210792
OWN - NLM
STAT- MEDLINE
DCOM- 20160906
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 31
IP  - 8
DP  - 2015 Dec
TI  - Systolic and diastolic myocardial mechanics in hypertrophic cardiomyopathy and 
      their link to the extent of hypertrophy, replacement fibrosis and interstitial 
      fibrosis.
PG  - 1603-10
LID - 10.1007/s10554-015-0720-0 [doi]
AB  - Aim of the present study was to investigate the relations between myocardial 
      mechanics and the extent of hypertrophy and fibrosis in hypertrophic 
      cardiomyopathy (HCM). Forty-five consecutive patients with HCM and 15 subjects 
      without structural heart disease were included. Cardiac magnetic resonance with 
      late gadolinium enhancement (LGE) imaging was performed to evaluate biventricular 
      function, LV mass index and presence/extent of LGE, expression of replacement 
      fibrosis. Myocardial T1 relaxation, a surrogate of interstitial fibrosis, was 
      measured from Look-Locker sequence. Feature-tracking analysis was applied to LV 
      basal, mid and apical short-axis images to assess systolic and diastolic global 
      LV circumferential strain (CS) and strain rate (CSr). Peak systolic CS and CSr 
      were significantly higher among HCM patients as compared to control subjects (p = 
      0.015 and p = 0.007, respectively). The ratio of peak CSr during early filling to 
      peak systolic CSr was significantly lower among HCM patients (p = 0.002). At 
      multivariate linear regression analysis, LV mass index (p < 0.001) and %LV LGE (p 
      = 0.011) were significantly and independently related to peak systolic CS; LV 
      mass index (p < 0.001) and %LV LGE (p = 0.023) were significantly and 
      independently related to peak systolic CSr; %LV LGE (p = 0.021) and T1 ratio (p = 
      0.006) were significantly and independently related to the ratio of peak CSr 
      during early filling to peak systolic CSr. LV systolic mechanics are enhanced and 
      LV diastolic mechanics are impaired in HCM. Extent of hypertrophy and replacement 
      fibrosis influence the LV systolic mechanics while extent of replacement fibrosis 
      and interstitial fibrosis influence the LV diastolic mechanics.
FAU - Nucifora, Gaetano
AU  - Nucifora G
AD  - Division of Cardiology, Cardiothoracic Department, University Hospital "Santa 
      Maria della Misericordia", Udine, Italy. gnucifora@outlook.com.
FAU - Muser, Daniele
AU  - Muser D
AD  - Division of Cardiology, Cardiothoracic Department, University Hospital "Santa 
      Maria della Misericordia", Udine, Italy.
FAU - Gianfagna, Pasquale
AU  - Gianfagna P
AD  - Division of Cardiology, Cardiothoracic Department, University Hospital "Santa 
      Maria della Misericordia", Udine, Italy.
FAU - Morocutti, Giorgio
AU  - Morocutti G
AD  - Division of Cardiology, Cardiothoracic Department, University Hospital "Santa 
      Maria della Misericordia", Udine, Italy.
FAU - Proclemer, Alessandro
AU  - Proclemer A
AD  - Division of Cardiology, Cardiothoracic Department, University Hospital "Santa 
      Maria della Misericordia", Udine, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150726
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomechanical Phenomena
MH  - Cardiomyopathy, Hypertrophic/*complications/pathology/physiopathology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Contrast Media/administration & dosage
MH  - *Diastole
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA/administration & dosage
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*etiology/pathology/physiopathology
MH  - Linear Models
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Stroke Volume
MH  - *Systole
MH  - Ventricular Dysfunction, Left/*etiology/pathology/physiopathology
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Feature-tracking
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Strain
OT  - T1 measurement
EDAT- 2015/07/27 06:00
MHDA- 2016/09/07 06:00
CRDT- 2015/07/27 06:00
PHST- 2015/05/25 00:00 [received]
PHST- 2015/07/22 00:00 [accepted]
PHST- 2015/07/27 06:00 [entrez]
PHST- 2015/07/27 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - 10.1007/s10554-015-0720-0 [pii]
AID - 10.1007/s10554-015-0720-0 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2015 Dec;31(8):1603-10. doi: 10.1007/s10554-015-0720-0. 
      Epub 2015 Jul 26.