PMID- 26210861
OWN - NLM
STAT- MEDLINE
DCOM- 20160308
LR  - 20220410
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 160
IP  - 5
DP  - 2015 Nov
TI  - Age, Sex, and Ethnic Variations in Inner and Outer Retinal and Choroidal 
      Thickness on Spectral-Domain Optical Coherence Tomography.
PG  - 1034-1043.e1
LID - S0002-9394(15)00451-1 [pii]
LID - 10.1016/j.ajo.2015.07.027 [doi]
AB  - PURPOSE: To evaluate age, sex, and ethnic variations in inner and outer retinal 
      and choroidal thickness and foveal pit, using spectral-domain optical coherence 
      tomography (SD OCT). DESIGN: Single-center observational cross-sectional study. 
      METHODS: Ninety randomly selected, healthy individuals of white, black, and South 
      Asian origin underwent SD OCT raster and enhanced depth imaging scan. Manual 
      measurements of inner and outer retinal thickness and choroidal thickness up to 
      3 mm nasal and temporal to the fovea were performed. The age, sex, and ethnic 
      differences in these parameters were analyzed. RESULTS: The mean inner retinal 
      thickness was lower by approximately 12 mum in black subjects across the central 
      retina compared to white subjects (P < .05). The central foveal thickness below 
      the foveal pit was lower in eyes of blacks compared to South Asians (12 mum, P = 
      .035) and white subjects (18 mum, P < .0001). The fovea was also significantly 
      wider in eyes of black and South Asian subjects compared to white individuals. 
      The inner retinal thickness decreased by 0.5 mum per year of age of subjects and 
      was thinner by 6.1 mum (P < .02) in female compared to male subjects. The 
      subfoveal choroidal thickness did not vary between ethnic groups but the temporal 
      choroid was significantly thinner in black subjects (P < .05). The choroid showed 
      an age-related decline in thickness of 2 mum per year of age of the subjects. 
      CONCLUSIONS: Interethnic differences include wider fovea, lower central foveal 
      thickness, and thinner inner retina in eyes of black subjects compared to their 
      white and South Asian counterparts.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Bafiq, Rinoza
AU  - Bafiq R
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom.
FAU - Mathew, Raeba
AU  - Mathew R
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom.
FAU - Pearce, Elizabeth
AU  - Pearce E
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom.
FAU - Abdel-Hey, Ahmed
AU  - Abdel-Hey A
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom.
FAU - Richardson, Matthew
AU  - Richardson M
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom.
FAU - Bailey, Thomas
AU  - Bailey T
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom.
FAU - Sivaprasad, Sobha
AU  - Sivaprasad S
AD  - King's College Hospital NHS Foundation Trust, London, United Kingdom. Electronic 
      address: senswathi@aol.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150722
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Aging/*ethnology
MH  - Choroid/*anatomy & histology
MH  - Cross-Sectional Studies
MH  - *Ethnicity
MH  - Female
MH  - Humans
MH  - Male
MH  - Reference Values
MH  - Tomography, Optical Coherence/*methods
MH  - United Kingdom
EDAT- 2015/07/27 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/07/27 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/07/07 00:00 [revised]
PHST- 2015/07/10 00:00 [accepted]
PHST- 2015/07/27 06:00 [entrez]
PHST- 2015/07/27 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - S0002-9394(15)00451-1 [pii]
AID - 10.1016/j.ajo.2015.07.027 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Nov;160(5):1034-1043.e1. doi: 10.1016/j.ajo.2015.07.027. 
      Epub 2015 Jul 22.