PMID- 26211893
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20220321
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 71
DP  - 2015 Sep
TI  - Spexin peptide is expressed in human endocrine and epithelial tissues and reduced 
      after glucose load in type 2 diabetes.
PG  - 232-9
LID - S0196-9781(15)00214-4 [pii]
LID - 10.1016/j.peptides.2015.07.018 [doi]
AB  - Spexin mRNA and protein are widely expressed in rat tissues and associate with 
      weight loss in rodents of diet-induced obesity. Its location in endocrine and 
      epithelial cells has also been suggested. Spexin is a novel peptide that involves 
      weight loss in rodents of diet-induced obesity. Therefore, we aimed to examine 
      its expression in human tissues and test whether spexin could have a role in 
      glucose and lipid metabolism in type 2 diabetes mellitus (T2DM). The expression 
      of the spexin gene and immunoreactivity in the adrenal gland, skin, stomach, 
      small intestine, liver, thyroid, pancreatic islets, visceral fat, lung, colon, 
      and kidney was higher than that in the muscle and connective tissue. 
      Immunoreactive serum spexin levels were reduced in T2DM patients and correlated 
      with fasting blood glucose (FBG, r=-0.686, P<0.001), hemoglobin A1c (HbA1c, 
      r=-0.632, P<0.001), triglyceride (TG, r=-0.236, P<0.001) and low density 
      lipoprotein-cholesterol (LDL-C, r=-0.382, P<0.001). A negative correlation of 
      blood glucose with spexin was observed during oral glucose tolerance test (OGTT). 
      Spexin is intensely expressed in normal human endocrine and epithelial tissues, 
      indicating that spexin may be involved in physiological functions of endocrine 
      and in several other tissues. Circulating spexin levels are low in T2DM patients 
      and negatively related to blood glucose and lipids suggesting that the peptide 
      may play a role in glucose and lipid metabolism in T2DM.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Gu, Liping
AU  - Gu L
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Ma, Yuhang
AU  - Ma Y
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Gu, Mingyu
AU  - Gu M
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Yan, Shuai
AU  - Yan S
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Li, Na
AU  - Li N
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Wang, Yufan
AU  - Wang Y
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Ding, Xiaoying
AU  - Ding X
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Yin, Jiajing
AU  - Yin J
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Fan, Nengguang
AU  - Fan N
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Peng, Yongde
AU  - Peng Y
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China. Electronic address: 
      pengyongde0908@126.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150723
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Peptide Hormones)
RN  - 0 (SPX protein, human)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*metabolism/pathology
MH  - Endocrine Glands/*metabolism
MH  - Epithelium/metabolism/pathology
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - Glucose/*administration & dosage
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organ Specificity
MH  - Peptide Hormones/*biosynthesis
OTO - NOTNLM
OT  - Endocrine tissue
OT  - Epithelial tissue
OT  - Humans
OT  - Spexin
OT  - Type 2 diabetes mellitus
EDAT- 2015/07/28 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/07/28 06:00
PHST- 2015/03/17 00:00 [received]
PHST- 2015/07/20 00:00 [revised]
PHST- 2015/07/20 00:00 [accepted]
PHST- 2015/07/28 06:00 [entrez]
PHST- 2015/07/28 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - S0196-9781(15)00214-4 [pii]
AID - 10.1016/j.peptides.2015.07.018 [doi]
PST - ppublish
SO  - Peptides. 2015 Sep;71:232-9. doi: 10.1016/j.peptides.2015.07.018. Epub 2015 Jul 
      23.