PMID- 2621383
OWN - NLM
STAT- MEDLINE
DCOM- 19900327
LR  - 20190820
IS  - 0387-5911 (Print)
IS  - 0387-5911 (Linking)
VI  - 63
IP  - 12
DP  - 1989 Dec
TI  - [Treatment of experimental murine candidiasis with liposome-encapsulated 
      amphotericin B].
PG  - 1301-7
AB  - Multilamellar liposomes composed of phosphatidyl choline, phosphatidic acid and 
      cholesterol at a molar ratio of 4:1:4 were prepared so as to entrap a solution of 
      amphotericin B (AMB) and its efficacy in the treatment of murine systemic 
      candidiasis were studied. There were marked differences in susceptibility to 
      systemic candidiasis among several strains of mice. The number of cultivable 
      Candida albicans increased remarkably in the kidney up to 6.4 X 10(5) c.f.u./g, 
      but not so marked in the lung, when challenged i.v. with 3.7 X 10(5) fungal cells 
      into a relatively resistant strain BALB/C mice. Liposome-encapsulated 
      amphotericin B (L-AMB) permitted larger doses of AMB to be administered without 
      the occurrence of the acute anaphylaxis-like and subacute toxicity as expressed 
      by a decreased renal function. The mice treated with a single injection of 4 
      mg/kg of L-AMB showed the prolonged survival after challenge. The results 
      obtained showed that the use of liposomes as a drug delivery system for AMB would 
      improve significantly the therapeutic efficacy of the antibiotic against 
      candidiasis.
FAU - Sasahara, T
AU  - Sasahara T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Kansenshogaku Zasshi
JT  - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious 
      Diseases
JID - 0236671
RN  - 0 (Drug Carriers)
RN  - 0 (Liposomes)
RN  - 7XU7A7DROE (Amphotericin B)
SB  - IM
MH  - Amphotericin B/*administration & dosage/therapeutic use
MH  - Animals
MH  - Candidiasis/*drug therapy
MH  - Drug Carriers
MH  - Female
MH  - Liposomes
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
AID - 10.11150/kansenshogakuzasshi1970.63.1301 [doi]
PST - ppublish
SO  - Kansenshogaku Zasshi. 1989 Dec;63(12):1301-7. doi: 
      10.11150/kansenshogakuzasshi1970.63.1301.