PMID- 26213920
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20221207
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 16
IP  - 8
DP  - 2015 Jul 23
TI  - Human Leukocyte Antigen Class II Alleles Are Associated with Hepatitis C Virus 
      Natural Susceptibility in the Chinese Population.
PG  - 16792-805
LID - 10.3390/ijms160816792 [doi]
AB  - Human leukocyte antigen (HLA) class II molecule influences host antigen 
      presentation and anti-viral immune response. The aim of this study was to 
      investigate whether single nucleotide polymorphisms (SNPs) within HLA class II 
      gene were associated with different clinical outcomes of hepatitis C virus (HCV) 
      infection. Three HLA class II SNPs (rs3077, rs2395309 and rs2856718) were 
      genotyped by TaqMan assay among Chinese population, including 350 persistent HCV 
      infection patients, 194 spontaneous viral clearance subjects and 973 
      HCV-uninfected control subjects. After logistic regression analysis, the results 
      indicated that the rs2856718 TC genotype was significantly associated with the 
      protective effect of the HCV natural susceptibility (adjusted OR: 0.712, 95% CI: 
      0.554-0.914) when compared with reference TT genotype, and this remained 
      significant after false discovery rate (FDR) correction (p = 0.024). Moreover, 
      the protective effect of rs2856718 was observed in dominant genetic models 
      (adjusted OR: 0.726, 95% CI: 0.574-0.920), and this remained significant after 
      FDR correction (p = 0.024). In stratified analysis, a significant decreased risk 
      was found in rs2856718C allele in the male subgroup (adjusted OR: 0.778, 95% CI: 
      0.627-0.966) and hemodialysis subgroup (adjusted OR: 0.713, 95% CI: 0.552-0.921). 
      Our results indicated that the genetic variations of rs2856718 within the HLA-DQ 
      gene are associated with the natural susceptibility to HCV infection among the 
      Chinese population.
FAU - Yue, Ming
AU  - Yue M
AD  - Department of Infectious Diseases, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing 210029, China. njym08@163.com.
FAU - Xu, Ke
AU  - Xu K
AD  - Department of Acute Infection Diseases, Jiangsu Province Center for Disease 
      Prevention and Control, Nanjing 210009, China. xuke923@163.com.
FAU - Wu, Meng-Ping
AU  - Wu MP
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. wumengping1990@163.com.
FAU - Han, Ya-Ping
AU  - Han YP
AD  - Department of Infectious Diseases, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing 210029, China. asian_peace@126.com.
FAU - Huang, Peng
AU  - Huang P
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. hp19880310@163.com.
FAU - Peng, Zhi-Hang
AU  - Peng ZH
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. zhihangpeng@njmu.edu.cn.
FAU - Wang, Jie
AU  - Wang J
AD  - School of Nursing, Nanjing Medical University, Nanjing 211166, China. 
      wangjie.nj@gmail.com.
FAU - Su, Jing
AU  - Su J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. sujing@njmu.edu.cn.
FAU - Yu, Rong-Bin
AU  - Yu RB
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. rongbinyu@njmu.edu.cn.
FAU - Li, Jun
AU  - Li J
AD  - Department of Infectious Diseases, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing 210029, China. dr-lijun@vip.sina.com.
FAU - Zhang, Yun
AU  - Zhang Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. zhangyunvip@126.com.
AD  - Institute of Epidemiology and Microbiology, Huadong Research Institute for 
      Medicine and Biotechnics, Nanjing 210002, China. zhangyunvip@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150723
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Demography
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Hepacivirus/*physiology
MH  - Hepatitis C/*genetics/*virology
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
PMC - PMC4581170
OTO - NOTNLM
OT  - hepatitis C virus
OT  - human leukocyte antigen
OT  - infection
OT  - outcome
OT  - polymorphism
EDAT- 2015/07/28 06:00
MHDA- 2016/04/29 06:00
PMCR- 2015/08/01
CRDT- 2015/07/28 06:00
PHST- 2015/05/29 00:00 [received]
PHST- 2015/07/16 00:00 [revised]
PHST- 2015/07/17 00:00 [accepted]
PHST- 2015/07/28 06:00 [entrez]
PHST- 2015/07/28 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - ijms160816792 [pii]
AID - ijms-16-16792 [pii]
AID - 10.3390/ijms160816792 [doi]
PST - epublish
SO  - Int J Mol Sci. 2015 Jul 23;16(8):16792-805. doi: 10.3390/ijms160816792.