PMID- 26214423
OWN - NLM
STAT- MEDLINE
DCOM- 20160518
LR  - 20161125
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Jul 6
TI  - Forkhead box protein O1 mediates apoptosis in a cancer cervical cell line treated 
      with the antitumor agent tumor necrosis factor-alpha.
PG  - 7446-54
LID - 10.4238/2015.July.3.20 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important pro-apoptotic cytokine, which 
      performs a broad range of immune and inflammatory functions in several vital 
      processes. TNF-alpha-induced apoptosis has been confirmed, however, relatively little 
      is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating 
      TNF-alpha-induced apoptosis in cervical cancer. In our study, we used the 
      well-characterized cervical cancer cell line C-33A to investigate the role of 
      FOXO1. The results showed that the antitumor agent TNF-alpha increased the expression 
      level of FOXO1 (P < 0.05) and enhanced its transcriptional activity (P < 0.05). 
      Furthermore, knockdown of FOXO1 repressed TNF-alpha-induced apoptosis and caspase-3, 
      8, and 9 expressions (P < 0.05). Collectively, these findings suggest that TNF-alpha 
      upregulated the transcriptional factor FOXO1, leading to an increased expression 
      of apoptotic gene, which leads to an increase in apoptosis.
FAU - Zhang, B
AU  - Zhang B
AD  - College of Animal Science and Technology, Northwest A & F University, Yangling, 
      Shaanxi, China.
FAU - Gui, L
AU  - Gui L
AD  - College of Animal Science and Technology, Northwest A & F University, Yangling, 
      Shaanxi, China.
FAU - Zhu, L
AU  - Zhu L
AD  - College of Basic Medical Sciences, Jiamusi University, Jiamusi, Heilongjiang, 
      China.
FAU - Zhao, X
AU  - Zhao X
AD  - College of Basic Medical Sciences, Jiamusi University, Jiamusi, Heilongjiang, 
      China.
FAU - Yang, Y
AU  - Yang Y
AD  - College of Basic Medical Sciences, Jiamusi University, Jiamusi, Heilongjiang, 
      China.
FAU - Li, Q
AU  - Li Q
AD  - College of Animal Science and Technology, Northwest A & F University, Yangling, 
      Shaanxi, China liqingwangysu@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150706
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Antineoplastic Agents)
RN  - 0 (FOXO1 protein, human)
RN  - 0 (Forkhead Box Protein O1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Caspases/metabolism
MH  - Cell Line, Tumor
MH  - Female
MH  - Forkhead Box Protein O1
MH  - Forkhead Transcription Factors/*biosynthesis/genetics
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - RNA, Small Interfering/administration & dosage/genetics
MH  - Recombinant Proteins/pharmacology
MH  - Transcription, Genetic
MH  - Transfection
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Up-Regulation/drug effects
MH  - Uterine Cervical Neoplasms/*drug therapy/genetics/metabolism/pathology
EDAT- 2015/07/28 06:00
MHDA- 2016/05/19 06:00
CRDT- 2015/07/28 06:00
PHST- 2015/07/28 06:00 [entrez]
PHST- 2015/07/28 06:00 [pubmed]
PHST- 2016/05/19 06:00 [medline]
AID - gmr5466 [pii]
AID - 10.4238/2015.July.3.20 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Jul 6;14(3):7446-54. doi: 10.4238/2015.July.3.20.