PMID- 26214901
OWN - NLM
STAT- MEDLINE
DCOM- 20150810
LR  - 20150728
IS  - 0564-3783 (Print)
IS  - 0564-3783 (Linking)
VI  - 49
IP  - 3
DP  - 2015 May-Jun
TI  - [MORPHOFUNCTIONAL PARAMETERS OF BLOOD CELLS OF THE RAT WITH 
      1,2-DIMETHYLHYDRAZINE-INDUCED COLON CARCINOGENESIS].
PG  - 17-24
AB  - Morphofunctional parameters of blood cells of the rats with dimethylhydrazine 
      induced colon carcinogenesis have been investigated. The reduction of Mean 
      corpuscular hemoglobin (MCH) and Mean corpuscular hemoglobin concentration (MCHC) 
      whereas increasing of reticulocytes number and indirect bilirubin after 20 weeks 
      of experiment of dimethylhydrazine (DMH)-induced colon carcinogenesis indicate 
      the hemolysis of red blood cells due to the DMH influence during tumors 
      development. The moderate increasing of monocytes and platelets number, as well 
      as increment of eosinophilic granulocytes number have been observed. 26 weeks of 
      experiment (after 6 weeks discontinuation of DMH) leads to reduction of 
      hemoglobin and erythrocytes number, a moderate increase of monocytes number and 
      increment of platelets number in rats blood. The anemia with thrombocytosis 
      accompany cancer in humans and the model of DMH-induced colon cancer is 
      appropriate not only for studies of carcinogenesis and searching of new 
      antineoplastic drugs, but also for the development of the correctional approaches 
      of cancer-associated changes in the hematopoietic system.
FAU - Byelinska, I V
AU  - Byelinska IV
FAU - Lynchak, O V
AU  - Lynchak OV
FAU - Rybalchenko, T V
AU  - Rybalchenko TV
FAU - Yablonska, S V
AU  - Yablonska SV
FAU - Bahurynska, O M
AU  - Bahurynska OM
FAU - Rybalchenko, V K
AU  - Rybalchenko VK
LA  - ukr
PT  - English Abstract
PT  - Journal Article
PL  - Ukraine
TA  - Tsitol Genet
JT  - TSitologiia i genetika
JID - 0101671
RN  - IX068S9745 (1,2-Dimethylhydrazine)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - 1,2-Dimethylhydrazine
MH  - Anemia/blood/chemically induced/complications/*pathology
MH  - Animals
MH  - Bilirubin/blood
MH  - Blood Cell Count
MH  - Blood Platelets/pathology
MH  - Carcinogenesis/metabolism/*pathology
MH  - Colorectal Neoplasms/blood/chemically induced/complications/*pathology
MH  - Disease Models, Animal
MH  - Eosinophils/pathology
MH  - Erythrocyte Indices
MH  - Erythrocytes/pathology
MH  - Hemolysis
MH  - Male
MH  - Monocytes/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Reticulocytes/pathology
MH  - Thrombosis/blood/chemically induced/complications/*pathology
EDAT- 2015/07/29 06:00
MHDA- 2015/08/11 06:00
CRDT- 2015/07/29 06:00
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2015/08/11 06:00 [medline]
PST - ppublish
SO  - Tsitol Genet. 2015 May-Jun;49(3):17-24.