PMID- 26214902
OWN - NLM
STAT- MEDLINE
DCOM- 20150810
LR  - 20190816
IS  - 0564-3783 (Print)
IS  - 0564-3783 (Linking)
VI  - 49
IP  - 3
DP  - 2015 May-Jun
TI  - IS THE AMPLIFICATION OF c-MYC, MLL AND RUNX1 GENES IN AML AND MDS PATIENTS WITH 
      TRISOMY 8, 11 AND 21 A FACTOR FOR A CLONAL EVOLUTION IN THEIR KARYOTYPE?
PG  - 25-32
AB  - The aim of our study was 1) to define if the amplification of c-MYC, MLL and 
      RUNX1 genes is related to the progressive changes of the karyotype in patients 
      with AML and MDS with trisomy 8, 11 and 21 (+8, +11 and +21) in bone marrow and 
      2) can that amplification be accepted as part of the clonal evolution (CE). 
      Karyotype analysis was performed in 179 patients with AML or MDS with the 
      different chromosomal aberrations (CA) aged 16-81. The findings were distributed 
      as follow: initiating balanced CA (n = 60), aneuploidia (n = 55), unbalanced CA 
      (n = 64). Amplification of c-MYC, MLL and RUNX1 genes by means of fluorescence in 
      situ hybridization (FISH) was found in 35% (7 out of 20) of AML and MDS patients 
      with +8, +11 u +21 as single CA in their karyotype; in 63.6% of pts (7 out of 
      11)--with additional numerical or structural CA and in 75% (9 out of 12)--with 
      complex karyotype. We assume that the amplification of the respective chromosomal 
      regions in patients with +8, +11 and +21 is related to CE. Considering the 
      amplification as a factor of CE, we established 3 patterns of karyotype 
      development depending on the type of the initiating CA in it. Significant 
      statistical differences were found between the three patterns regarding the 
      karyotype distribution in the different stages of progression (p < 0.001).
FAU - Angelova, S
AU  - Angelova S
FAU - Spassov, B
AU  - Spassov B
FAU - Nikolova, V
AU  - Nikolova V
FAU - Christov, I
AU  - Christov I
FAU - Tzvetkov, N
AU  - Tzvetkov N
FAU - Simeonova, M
AU  - Simeonova M
LA  - eng
PT  - Journal Article
PL  - Ukraine
TA  - Tsitol Genet
JT  - TSitologiia i genetika
JID - 0101671
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (RUNX1 protein, human)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
RN  - Chromosome 11q trisomy
RN  - Chromosome 8, trisomy
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow/metabolism/pathology
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 8
MH  - Clonal Evolution
MH  - Core Binding Factor Alpha 2 Subunit/*genetics
MH  - Disease Progression
MH  - *Down Syndrome
MH  - Female
MH  - Gene Dosage
MH  - Histone-Lysine N-Methyltransferase/*genetics
MH  - Humans
MH  - Karyotype
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics/pathology
MH  - Myeloid-Lymphoid Leukemia Protein/*genetics
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - *Trisomy
EDAT- 2015/07/29 06:00
MHDA- 2015/08/11 06:00
CRDT- 2015/07/29 06:00
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2015/08/11 06:00 [medline]
PST - ppublish
SO  - Tsitol Genet. 2015 May-Jun;49(3):25-32.