PMID- 26214997
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20151119
IS  - 0019-5499 (Print)
IS  - 0019-5499 (Linking)
VI  - 58
IP  - 4
DP  - 2014 Oct-Dec
TI  - Effect of Orexin-A infusion in to the Nucleus Accumbens on consummatory behaviour 
      and alcohol preference in male Wistar rats.
PG  - 319-26
AB  - BACKGROUND: Effect of administration of Orexin-A into nucleus accumbens (NAcc) in 
      relation to the regulation of feeding behavior and alcohol consumption at 
      specific time intervals is relatively unknown. MATERIALS AND METHODS: In this 
      study, Male Wistar albino rats (n = 54) weighing about 250 +/- 10 grams were 
      implanted bilaterally with guide cannula (22 gauze) to target NAcc by stereotaxic 
      surgery. Saline (0.9%) for control and Orexin-A for experimental groups (100 pmol 
      or 250 pmol) were infused by Harvard picoplus pump. Food, water and alcohol (10%) 
      consumption were measured at 1, 2, 4 and 24 hours to evaluate the effect of 
      Orexin-A in fasted rats (24 hours). Preference study was carried out by two 
      bottle choice test. RESULTS: Orexin-A infusion into NAcc showed significant 
      increase in food at 1 hr in all groups compared to controls (p < 0.05) and 
      alcohol (p < 0.02) intake. The changes were dose dependent. There was no 
      noticeable preference or alcohol. CONCLUSIONS FOR: These findings showed that 
      Orexin-A in NAcc could be involved in feeding and drinking but not alcohol 
      preference. The results highlight the effect of Orexin A infusion into NAcc in 
      consummatory behaviour besides other hypothalamic and mesolimbic centres.
FAU - Mayannavar, Santosh
AU  - Mayannavar S
FAU - Rashmi, K S
AU  - Rashmi KS
FAU - Rao, Yalla Durga
AU  - Rao YD
FAU - Yadav, Saraswati
AU  - Yadav S
FAU - Ganaraja, B
AU  - Ganaraja B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Physiol Pharmacol
JT  - Indian journal of physiology and pharmacology
JID - 0374707
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
SB  - IM
MH  - Alcohol Drinking/*drug therapy
MH  - Animals
MH  - Behavior, Animal
MH  - Choice Behavior/*drug effects
MH  - Consummatory Behavior/*drug effects
MH  - Eating/drug effects
MH  - Intracellular Signaling Peptides and Proteins/*pharmacology
MH  - Male
MH  - Neuropeptides/*pharmacology
MH  - Nucleus Accumbens/*drug effects/physiology
MH  - Orexins
MH  - Rats
MH  - Rats, Wistar
EDAT- 2015/07/29 06:00
MHDA- 2015/08/22 06:00
CRDT- 2015/07/29 06:00
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
PST - ppublish
SO  - Indian J Physiol Pharmacol. 2014 Oct-Dec;58(4):319-26.