PMID- 26215259
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20220222
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 11
IP  - 9
DP  - 2015 Sep
TI  - Physiological and pathophysiological roles of NAMPT and NAD metabolism.
PG  - 535-46
LID - 10.1038/nrendo.2015.117 [doi]
AB  - Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the 
      intracellular nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential 
      coenzyme involved in cellular redox reactions and is a substrate for 
      NAD-dependent enzymes. In various metabolic disorders and during ageing, levels 
      of NAD are decreased. Through its NAD-biosynthetic activity, NAMPT influences the 
      activity of NAD-dependent enzymes, thereby regulating cellular metabolism. In 
      addition to its enzymatic function, extracellular NAMPT (eNAMPT) has 
      cytokine-like activity. Abnormal levels of eNAMPT are associated with various 
      metabolic disorders. NAMPT is able to modulate processes involved in the 
      pathogenesis of obesity and related disorders such as nonalcoholic fatty liver 
      disease (NAFLD) and type 2 diabetes mellitus (T2DM) by influencing the oxidative 
      stress response, apoptosis, lipid and glucose metabolism, inflammation and 
      insulin resistance. NAMPT also has a crucial role in cancer cell metabolism, is 
      often overexpressed in tumour tissues and is an experimental target for 
      antitumour therapies. In this Review, we discuss current understanding of the 
      functions of NAMPT and highlight progress made in identifying the physiological 
      role of NAMPT and its relevance in various human diseases and conditions, such as 
      obesity, NAFLD, T2DM, cancer and ageing.
FAU - Garten, Antje
AU  - Garten A
AD  - Center for Pediatric Research Leipzig, Hospital for Children and Adolescents, 
      University of Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany.
FAU - Schuster, Susanne
AU  - Schuster S
AD  - Center for Pediatric Research Leipzig, Hospital for Children and Adolescents, 
      University of Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany.
FAU - Penke, Melanie
AU  - Penke M
AD  - Center for Pediatric Research Leipzig, Hospital for Children and Adolescents, 
      University of Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany.
FAU - Gorski, Theresa
AU  - Gorski T
AD  - Center for Pediatric Research Leipzig, Hospital for Children and Adolescents, 
      University of Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany.
FAU - de Giorgis, Tommaso
AU  - de Giorgis T
AD  - Center for Pediatric Research Leipzig, Hospital for Children and Adolescents, 
      University of Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany.
FAU - Kiess, Wieland
AU  - Kiess W
AD  - Center for Pediatric Research Leipzig, Hospital for Children and Adolescents, 
      University of Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150728
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
RN  - 0 (Cytokines)
RN  - 0U46U6E8UK (NAD)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
SB  - IM
MH  - Animals
MH  - Cytokines/*genetics/*physiology
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Humans
MH  - NAD/*metabolism
MH  - Nicotinamide Phosphoribosyltransferase/*genetics/*physiology
MH  - Obesity/enzymology/genetics
EDAT- 2015/07/29 06:00
MHDA- 2016/03/22 06:00
CRDT- 2015/07/29 06:00
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
AID - nrendo.2015.117 [pii]
AID - 10.1038/nrendo.2015.117 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2015 Sep;11(9):535-46. doi: 10.1038/nrendo.2015.117. Epub 
      2015 Jul 28.