PMID- 26216489
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20150812
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 86
IP  - 3
DP  - 2015 Sep
TI  - Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts 
      with HLA-A24-restricted ovarian cancer-specific CTLs.
PG  - 164-71
LID - 10.1111/tan.12607 [doi]
AB  - Here, we describe an human leukocyte antigen (HLA)-A*24:02-restricted cytotoxic 
      T-lymphocyte (CTL) clone, 1G3, established from naive CD8(+) T-lymphocytes 
      obtained from a healthy donor stimulated with HLA-modified TOV21G, an ovarian 
      cancer cell line. The 1G3 clone responds not only to ovarian cancer cells in the 
      context of HLA-A*24:02 but also to allogeneic HLA-Cw*07:02 molecules through 
      cross-reactive T-cell receptor recognition. Expression screening using a 
      complementary DNA library constructed from TOV21G messenger RNA revealed that 
      this alloreactivity was mediated through the nine-mer peptide VRTPYTMSY, derived 
      from RNA-binding motif protein 4. To our knowledge, this study presents the first 
      example of the allorecognition of an HLA-Cw molecule by HLA-A-restricted T-cells, 
      thereby revealing a naturally processed epitope peptide. These findings provide 
      the structural bases for the allorecognition of human T-cells. In addition, this 
      study suggests that unexpected alloresponses occur in certain HLA combinations, 
      and further study is needed to understand the mechanisms of alloreactivity for 
      better prediction of alloresponses in clinical settings.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Yamada, E
AU  - Yamada E
AD  - Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
AD  - Department of Gynecology, Graduate School of Medicine, Nagoya, Japan.
FAU - Demachi-Okamura, A
AU  - Demachi-Okamura A
AD  - Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
FAU - Kondo, S
AU  - Kondo S
AD  - Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
FAU - Akatsuka, Y
AU  - Akatsuka Y
AD  - Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
AD  - Department of Hematology & Oncology, Fujita Health University, Toyoake, Japan.
FAU - Suzuki, S
AU  - Suzuki S
AD  - Department of Gynecology, Graduate School of Medicine, Nagoya, Japan.
FAU - Shibata, K
AU  - Shibata K
AD  - Department of Gynecology, Graduate School of Medicine, Nagoya, Japan.
FAU - Kikkawa, F
AU  - Kikkawa F
AD  - Department of Gynecology, Graduate School of Medicine, Nagoya, Japan.
FAU - Kuzushima, K
AU  - Kuzushima K
AD  - Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
AD  - Department of Cellular Oncology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150728
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (DNA, Complementary)
RN  - 0 (Epitopes)
RN  - 0 (HLA-A*24:02 antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*70 antigen)
RN  - 0 (Peptides)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Cell Line, Tumor
MH  - Clone Cells
MH  - Cross Reactions/*immunology
MH  - DNA, Complementary/genetics
MH  - Epitopes/immunology
MH  - Female
MH  - HEK293 Cells
MH  - HLA-A24 Antigen/*immunology
MH  - HLA-C Antigens/*immunology
MH  - Humans
MH  - Molecular Sequence Data
MH  - Ovarian Neoplasms/*immunology/pathology
MH  - Peptides/chemistry/*metabolism
MH  - Protein Binding
MH  - *Protein Processing, Post-Translational
MH  - RNA-Binding Proteins/chemistry/metabolism
MH  - T-Lymphocytes, Cytotoxic/*immunology
OTO - NOTNLM
OT  - HLA-A*24:02
OT  - HLA-Cw*07:02
OT  - alloreactivity
OT  - antigen-presenting cells
OT  - cytotoxic T-lymphocyte
OT  - ovarian cancer
EDAT- 2015/07/29 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/07/29 06:00
PHST- 2015/02/12 00:00 [received]
PHST- 2015/05/13 00:00 [revised]
PHST- 2015/06/17 00:00 [accepted]
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - 10.1111/tan.12607 [doi]
PST - ppublish
SO  - Tissue Antigens. 2015 Sep;86(3):164-71. doi: 10.1111/tan.12607. Epub 2015 Jul 28.