PMID- 26217791
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150728
LR  - 20200930
IS  - 2352-3409 (Print)
IS  - 2352-3409 (Electronic)
IS  - 2352-3409 (Linking)
VI  - 4
DP  - 2015 Sep
TI  - Quantitative analysis of PPT1 interactome in human neuroblastoma cells.
PG  - 207-16
LID - 10.1016/j.dib.2015.05.016 [doi]
AB  - Mutations in the CLN1 gene that encodes Palmitoyl protein thioesterase 1 (PPT1) 
      or CLN1, cause Infantile NCL (INCL, MIM#256730). PPT1 removes long fatty acid 
      chains such as palmitate from modified cysteine residues of proteins. The data 
      shown here result from isolated protein complexes from PPT1-expressing SH-SY5Y 
      stable cells that were subjected to single step affinity purification coupled to 
      mass spectrometry (AP-MS). Prior to the MS analysis, we utilised a modified 
      filter-aided sample preparation (FASP) protocol. Based on label free quantitative 
      analysis of the data by SAINT, 23 PPT1 interacting partners (IP) were identified. 
      A dense connectivity in PPT1 network was further revealed by functional coupling 
      and extended network analyses, linking it to mitochondrial ATP synthesis coupled 
      protein transport and thioester biosynthetic process. Moreover, the terms: 
      inhibition of organismal death, movement disorders and concentration of lipid 
      were predicted to be altered in the PPT1 network. Data presented here are related 
      to Scifo et al. (J. Proteomics, 123 (2015) 42-53).
FAU - Scifo, Enzo
AU  - Scifo E
AD  - Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine, 
      Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland 
      ; Doctoral Program Brain & Mind, University of Helsinki, Helsinki, Finland.
FAU - Szwajda, Agnieszka
AU  - Szwajda A
AD  - Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, 
      Finland.
FAU - Soliymani, Rabah
AU  - Soliymani R
AD  - Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine, 
      Biochemistry and Developmental Biology, University of Helsinki, Helsinki, 
      Finland.
FAU - Pezzini, Francesco
AU  - Pezzini F
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona, 
      Italy.
FAU - Bianchi, Marzia
AU  - Bianchi M
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona, 
      Italy ; Unit for Neuromuscular and Neurodegenerative Disorders, Laboratory of 
      Molecular Medicine, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
FAU - Dapkunas, Arvydas
AU  - Dapkunas A
AD  - Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine, 
      Biochemistry and Developmental Biology, University of Helsinki, Helsinki, 
      Finland.
FAU - Debski, Janusz
AU  - Debski J
AD  - Mass Spectrometry Laboratory, Department of Biophysics, Institute of Biochemistry 
      and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
FAU - Uusi-Rauva, Kristiina
AU  - Uusi-Rauva K
AD  - Folkhalsan Institute of Genetics, Helsinki, Finland ; National Institute for 
      Health and Welfare, Public Health Genomics Unit, Helsinki, Finland.
FAU - Dadlez, Michal
AU  - Dadlez M
AD  - Mass Spectrometry Laboratory, Department of Biophysics, Institute of Biochemistry 
      and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
FAU - Gingras, Anne-Claude
AU  - Gingras AC
AD  - Centre for Systems Biology, Samuel Lunenfeld Research Institute at Mount Sinai 
      Hospital, Toronto, and Department of Molecular Genetics, University of Toronto, 
      Toronto, ON, Canada.
FAU - Tyynela, Jaana
AU  - Tyynela J
AD  - Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine, 
      Biochemistry and Developmental Biology, University of Helsinki, Helsinki, 
      Finland.
FAU - Simonati, Alessandro
AU  - Simonati A
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona, 
      Italy.
FAU - Jalanko, Anu
AU  - Jalanko A
AD  - Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, 
      Finland ; National Institute for Health and Welfare, Public Health Genomics Unit, 
      Helsinki, Finland.
FAU - Baumann, Marc H
AU  - Baumann MH
AD  - Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine, 
      Biochemistry and Developmental Biology, University of Helsinki, Helsinki, 
      Finland.
FAU - Lalowski, Maciej
AU  - Lalowski M
AD  - Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine, 
      Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland 
      ; Folkhalsan Institute of Genetics, Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20150612
PL  - Netherlands
TA  - Data Brief
JT  - Data in brief
JID - 101654995
PMC - PMC4510454
EDAT- 2015/07/29 06:00
MHDA- 2015/07/29 06:01
PMCR- 2015/06/12
CRDT- 2015/07/29 06:00
PHST- 2015/05/18 00:00 [received]
PHST- 2015/05/28 00:00 [revised]
PHST- 2015/05/29 00:00 [accepted]
PHST- 2015/07/29 06:00 [entrez]
PHST- 2015/07/29 06:00 [pubmed]
PHST- 2015/07/29 06:01 [medline]
PHST- 2015/06/12 00:00 [pmc-release]
AID - S2352-3409(15)00084-0 [pii]
AID - 10.1016/j.dib.2015.05.016 [doi]
PST - epublish
SO  - Data Brief. 2015 Jun 12;4:207-16. doi: 10.1016/j.dib.2015.05.016. eCollection 
      2015 Sep.