PMID- 26220945
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20221207
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 38
IP  - 10
DP  - 2015 Oct
TI  - Fasting until noon triggers increased postprandial hyperglycemia and impaired 
      insulin response after lunch and dinner in individuals with type 2 diabetes: a 
      randomized clinical trial.
PG  - 1820-6
LID - 10.2337/dc15-0761 [doi]
AB  - OBJECTIVE: Skipping breakfast has been consistently associated with high HbA1c 
      and postprandial hyperglycemia (PPHG) in patients with type 2 diabetes. Our aim 
      was to explore the effect of skipping breakfast on glycemia after a subsequent 
      isocaloric (700 kcal) lunch and dinner. RESEARCH DESIGN AND METHODS: In a 
      crossover design, 22 patients with diabetes with a mean diabetes duration of 8.4 
      +/- 0.7 years, age 56.9 +/- 1.0 years, BMI 28.2 +/- 0.6 kg/m(2), and HbA1c 7.7 +/- 0.1% 
      (61 +/- 0.8 mmol/mol) were randomly assigned to two test days: one day with 
      breakfast, lunch, and dinner (YesB) and another with lunch and dinner but no 
      breakfast (NoB). Postprandial plasma glucose, insulin, C-peptide, free fatty 
      acids (FFA), glucagon, and intact glucagon-like peptide-1 (iGLP-1) were assessed. 
      RESULTS: Compared with YesB, lunch area under the curves for 0-180 min (AUC0-180) 
      for plasma glucose, FFA, and glucagon were 36.8, 41.1, and 14.8% higher, 
      respectively, whereas the AUC0-180 for insulin and iGLP-1 were 17% and 19% lower, 
      respectively, on the NoB day (P < 0.0001). Similarly, dinner AUC0-180 for 
      glucose, FFA, and glucagon were 26.6, 29.6, and 11.5% higher, respectively, and 
      AUC0-180 for insulin and iGLP-1 were 7.9% and 16.5% lower on the NoB day compared 
      with the YesB day (P < 0.0001). Furthermore, insulin peak was delayed 30 min 
      after lunch and dinner on the NoB day compared with the YesB day. CONCLUSIONS: 
      Skipping breakfast increases PPHG after lunch and dinner in association with 
      lower iGLP-1 and impaired insulin response. This study shows a long-term 
      influence of breakfast on glucose regulation that persists throughout the day. 
      Breakfast consumption could be a successful strategy for reduction of PPHG in 
      type 2 diabetes.
CI  - (c) 2015 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Jakubowicz, Daniela
AU  - Jakubowicz D
AD  - Diabetes Unit, Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv 
      University, Holon, Israel Diabetes Unit, Department of Internal Medicine, 
      Hospital de Clinicas Caracas, Central University of Venezuela, Caracas, Venezuela 
      daniela.jak@gmail.com oren.froy@mail.huji.ac.il.
FAU - Wainstein, Julio
AU  - Wainstein J
AD  - Diabetes Unit, Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv 
      University, Holon, Israel.
FAU - Ahren, Bo
AU  - Ahren B
AD  - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, 
      Sweden.
FAU - Landau, Zohar
AU  - Landau Z
AD  - Diabetes Unit, Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv 
      University, Holon, Israel.
FAU - Bar-Dayan, Yosefa
AU  - Bar-Dayan Y
AD  - Diabetes Unit, Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv 
      University, Holon, Israel.
FAU - Froy, Oren
AU  - Froy O
AD  - Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of 
      Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 
      Israel daniela.jak@gmail.com oren.froy@mail.huji.ac.il.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150728
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9007-92-5 (Glucagon)
SB  - IM
CIN - Nat Rev Endocrinol. 2015 Oct;11(10):566. PMID: 26284449
CIN - Diabetes Care. 2016 Feb;39(2):e28. PMID: 26798157
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Breakfast
MH  - C-Peptide/blood
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - *Fasting
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Glucagon/blood
MH  - Glucagon-Like Peptide 1/blood
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hyperglycemia/*blood
MH  - Insulin/*blood
MH  - Lunch
MH  - Male
MH  - Meals
MH  - Middle Aged
MH  - Postprandial Period
EDAT- 2015/07/30 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/07/30 06:00
PHST- 2015/04/12 00:00 [received]
PHST- 2015/06/17 00:00 [accepted]
PHST- 2015/07/30 06:00 [entrez]
PHST- 2015/07/30 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - dc15-0761 [pii]
AID - 10.2337/dc15-0761 [doi]
PST - ppublish
SO  - Diabetes Care. 2015 Oct;38(10):1820-6. doi: 10.2337/dc15-0761. Epub 2015 Jul 28.