PMID- 26221138
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150729
LR  - 20200930
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2015
DP  - 2015
TI  - Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active 
      Graves' Orbitopathy.
PG  - 285698
LID - 10.1155/2015/285698 [doi]
LID - 285698
AB  - Aim. To study the efficacy and safety of subantimicrobial dose (SD) 
      doxycycline(50 mg/d) in patients with active and moderate-to-severe Graves' 
      orbitopathy (GO). Methods. Thirteen patients with active and moderate-to-severe 
      GO received once daily oral doxycycline (50 mg/d) for 12 wk. Treatment response 
      at 24 wk was used as the primary outcome, measured by a composite of improvement 
      in Clinical Activity Score (CAS), diplopia, motility, soft tissue swelling, 
      proptosis, and eyelid aperture. Secondary outcome was the change of quality of 
      life score (QoL, including visual functioning subscale and appearance subscale). 
      Adverse events were also recorded. Results. Overall improvement was noted in 
      eight out of 13 patients (61.5%, 95% CI 31.6%-86.1%). Both CAS and soft tissue 
      swelling significantly ameliorated in eight patients at 24 wk. Five patients 
      (38.5%) had improvement in ocular motility of >/=8 degrees. Eyelid aperture (46.2%) 
      also decreased remarkably. For QoL, a significant improvement in appearance 
      subscale (P = 0.008) was noted during the study, whereas no difference was 
      observed in visual functioning subscale (P = 0.21). Two patients reported mild 
      stomachache at 12 wk. Conclusions. SD doxycycline appears to be effective and 
      safe for the treatment of active and moderate-to-severe GO. It might serve as a 
      new promising therapeutic strategy for GO. This trial is registered with 
      NCT01727973.
FAU - Lin, Miaoli
AU  - Lin M
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Mao, Yuxiang
AU  - Mao Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Ai, Siming
AU  - Ai S
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Liu, Guangming
AU  - Liu G
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Yan, Jianhua
AU  - Yan J
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Yang, Huasheng
AU  - Yang H
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Li, Aimin
AU  - Li A
AD  - 458th Hospital of PLA, Guangzhou 510602, China.
FAU - Zou, Yusha
AU  - Zou Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
FAU - Liang, Dan
AU  - Liang D
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, No. 54 Xianlie Road, Guangzhou 510060, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT01727973
PT  - Journal Article
DEP - 20150629
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC4499606
EDAT- 2015/07/30 06:00
MHDA- 2015/07/30 06:01
PMCR- 2015/06/29
CRDT- 2015/07/30 06:00
PHST- 2014/05/01 00:00 [received]
PHST- 2014/07/21 00:00 [revised]
PHST- 2014/08/11 00:00 [accepted]
PHST- 2015/07/30 06:00 [entrez]
PHST- 2015/07/30 06:00 [pubmed]
PHST- 2015/07/30 06:01 [medline]
PHST- 2015/06/29 00:00 [pmc-release]
AID - 10.1155/2015/285698 [doi]
PST - ppublish
SO  - Int J Endocrinol. 2015;2015:285698. doi: 10.1155/2015/285698. Epub 2015 Jun 29.