PMID- 26221150
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150729
LR  - 20200930
IS  - 1735-0344 (Print)
IS  - 2345-3729 (Electronic)
IS  - 1735-0344 (Linking)
VI  - 14
IP  - 1
DP  - 2015
TI  - Association of High Sensitive CRP Level and COPD Assessment Test Scores with 
      Clinically Important Predictive Outcomes in Stable COPD Patients.
PG  - 34-41
AB  - BACKGROUND: High sensitive CRP (hs-CRP) is used as a marker of systemic 
      inflammation in chronic obstructive pulmonary disease (COPD). However, we 
      hypothesize that the raised hs-CRP is not closely related to the multiple 
      consequences of COPD. This study was undertaken to investigate the association of 
      COPD assessment test (CAT) score with SpO2, FEV1, body mass index (BMI), 
      obstruction, dyspnea and exercise capacity (BODE) index and COPD exacerbation 
      rate and compare it with the association to serum hs-CRP level. MATERIALS AND 
      METHODS: Sixty patients with stable COPD referred to the pulmonology clinic of 
      Ardabil Imam Khomeini Hospital were included in this study. SpO2, 6-minute walk 
      distance (6MWD), body mass index, BODE index, and pulmonary function test as well 
      as exacerbation rate were determined in COPD patients. Then, the CAT 
      questionnaire was completed by patients. Serum level of hs-CRP was measured in 
      all patients and 15 controls. We statistically compared the relationships and 
      correlations among the variables. RESULTS: Hs-CRP level was significantly raised 
      in patients (P=0.005). In these patients, the correlation of hs-CRP level with 
      BODE index was significant (P=0.008). However, the correlation of hs-CRP with 
      SpO2 and FEV1 was not significant (P=0.47 and P=0.17, respectively). Also, the 
      correlation of CAT score with SpO2, FEV1, BODE index, and exacerbation rate in 
      the previous year was significant (P<0.001, P<0.001, P<0.001 and P=0.017, 
      respectively). CONCLUSION: SpO2, FEV1, BODE index and exacerbation rate are more 
      correlated with CAT scores than with the serum level of hs-CRP in stable COPD 
      patients. The findings of this study should be considered in management of stable 
      COPD patients.
FAU - Ghobadi, Hassan
AU  - Ghobadi H
AD  - Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, 
      Iran.
FAU - Fouladi, Nasrin
AU  - Fouladi N
AD  - Department of Community Medicine, Ardabil University of Medical Sciences, 
      Ardabil, Iran.
FAU - Beukaghazadeh, Katrin
AU  - Beukaghazadeh K
AD  - Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, 
      Iran.
FAU - Ansarin, Khalil
AU  - Ansarin K
AD  - Tuberculosis and Lung Disease Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Tanaffos
JT  - Tanaffos
JID - 101308232
PMC - PMC4515328
OTO - NOTNLM
OT  - BODE index
OT  - C-Reactive Protein
OT  - COPD
OT  - COPD assessment test
OT  - hs-CRP
EDAT- 2015/07/30 06:00
MHDA- 2015/07/30 06:01
PMCR- 2015/01/01
CRDT- 2015/07/30 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/11/22 00:00 [accepted]
PHST- 2015/07/30 06:00 [entrez]
PHST- 2015/07/30 06:00 [pubmed]
PHST- 2015/07/30 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - tanaffos-14-34 [pii]
PST - ppublish
SO  - Tanaffos. 2015;14(1):34-41.