PMID- 26221831
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20220408
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 26
IP  - 6
DP  - 2015 Sep
TI  - Effect of drugs of abuse on social behaviour: a review of animal models.
PG  - 541-70
LID - 10.1097/FBP.0000000000000162 [doi]
AB  - Social behaviour is disturbed in many substance abuse and psychiatric disorders. 
      Given the consensus that social behaviours of lower mammals may help to 
      understand some human emotional reactions, the aim of the present work was to 
      provide an up-to-date review of studies on the changes in social behaviour 
      induced by drugs of abuse. Various animal models have been used to study the 
      relationship between drugs of abuse and social behaviour. Herein, we describe the 
      effects of different substances of abuse on the three most commonly used animal 
      models of social behaviour: the social play test, the social interaction test and 
      the resident-intruder paradigm. The first is the most widely used test to assess 
      adolescent behaviour in rodents, the second is generally used to evaluate a wide 
      repertoire of behaviours in adulthood and the latter is specific to aggressive 
      behaviour. Throughout the review we will explore the most relevant studies 
      carried out to date to evaluate the effects of alcohol, cocaine, opioids, 
      3,4-methylenedioxymethamphetamine (MDMA), cannabinoids, nicotine and other drugs 
      of abuse on these three paradigms, taking into account the influence of different 
      variables, such as social history, age and type of exposure. Drugs of diverse 
      pharmacological classes induce alterations in social behaviour, although they can 
      be contrasting depending on several factors (drug, individual differences and 
      environmental conditions). Ethanol and nicotine increase social interaction at 
      low doses but reduce it at high doses. Psychostimulants, MDMA and cannabinoids 
      reduce social interaction, whereas opiates increase it. Ethanol and 
      psychostimulants enhance aggression, whereas MDMA, opiates, cannabinoids and 
      nicotine reduce it. Prenatal drug exposure alters social behaviour, whereas drug 
      withdrawal decreases sociability and enhances aggression. As a whole, this 
      evidence has improved our understanding of the social dimension of drug 
      addiction.
FAU - Blanco-Gandia, Maria C
AU  - Blanco-Gandia MC
AD  - Unit of Research on Psychobiology of Drug Dependence. Department of 
      Psychobiology, Faculty of Psychology, Universitat de Valencia, Valencia, Spain.
FAU - Mateos-Garcia, Ana
AU  - Mateos-Garcia A
FAU - Garcia-Pardo, Maria P
AU  - Garcia-Pardo MP
FAU - Montagud-Romero, Sandra
AU  - Montagud-Romero S
FAU - Rodriguez-Arias, Marta
AU  - Rodriguez-Arias M
FAU - Minarro, Jose
AU  - Minarro J
FAU - Aguilar, Maria A
AU  - Aguilar MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Illicit Drugs/*pharmacology
MH  - *Models, Animal
MH  - *Social Behavior
MH  - Substance-Related Disorders/etiology/*psychology
EDAT- 2015/07/30 06:00
MHDA- 2016/05/06 06:00
CRDT- 2015/07/30 06:00
PHST- 2015/07/30 06:00 [entrez]
PHST- 2015/07/30 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
AID - 00008877-201509000-00005 [pii]
AID - 10.1097/FBP.0000000000000162 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2015 Sep;26(6):541-70. doi: 10.1097/FBP.0000000000000162.