PMID- 26225223
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150730
LR  - 20181113
IS  - 2163-8306 (Print)
IS  - 2163-8306 (Electronic)
IS  - 2163-8306 (Linking)
VI  - 4
IP  - 1
DP  - 2015 Jan
TI  - The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes Mellitus 
      Quantified by an Integrated Glucose Insulin Model.
PG  - e00011
LID - 10.1002/psp4.11 [doi]
LID - e00011
AB  - In recent years, several glucagon-like peptide-1 (GLP-1)-based therapies for the 
      treatment of type 2 diabetes mellitus (T2DM) have been developed. The aim of this 
      work was to extend the semimechanistic integrated glucose-insulin model to 
      include the effects of a GLP-1 analog on glucose homeostasis in T2DM patients. 
      Data from two trials comparing the effect of steady-state liraglutide vs. placebo 
      on the responses of postprandial glucose and insulin in T2DM patients were used 
      for model development. The effect of liraglutide was incorporated in the model by 
      including a stimulatory effect on insulin secretion. Furthermore, for one of the 
      trials an inhibitory effect on glucose absorption was included to account for a 
      delay in gastric emptying. As other GLP-1 receptor agonists have similar modes of 
      action, it is believed that the model can also be used to describe the effect of 
      other receptor agonists on glucose homeostasis.
FAU - Roge, R M
AU  - Roge RM
AD  - Novo Nordisk A/S Soborg, Denmark ; Department of Pharmaceutical Biosciences, 
      Uppsala University Uppsala, Sweden.
FAU - Klim, S
AU  - Klim S
AD  - Novo Nordisk A/S Soborg, Denmark.
FAU - Ingwersen, S H
AU  - Ingwersen SH
AD  - Novo Nordisk A/S Soborg, Denmark.
FAU - Kjellsson, M C
AU  - Kjellsson MC
AD  - Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
FAU - Kristensen, N R
AU  - Kristensen NR
AD  - Novo Nordisk A/S Soborg, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20141230
PL  - United States
TA  - CPT Pharmacometrics Syst Pharmacol
JT  - CPT: pharmacometrics & systems pharmacology
JID - 101580011
PMC - PMC4369758
EDAT- 2015/08/01 06:00
MHDA- 2015/08/01 06:01
PMCR- 2015/01/01
CRDT- 2015/07/31 06:00
PHST- 2014/09/08 00:00 [received]
PHST- 2014/11/04 00:00 [accepted]
PHST- 2015/07/31 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2015/08/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.1002/psp4.11 [doi]
PST - ppublish
SO  - CPT Pharmacometrics Syst Pharmacol. 2015 Jan;4(1):e00011. doi: 10.1002/psp4.11. 
      Epub 2014 Dec 30.