PMID- 26225651
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 13
DP  - 2015
TI  - beta-Catenin Alterations in Squamous Cell Carcinoma of the Lip.
PG  - 5187-90
AB  - This study aimed to investigate the correlation between beta-catenin 
      immunoexpression and histopathological grades of lower lip squamous cell 
      carcinoma (LSCC). beta-Catenin abnormal expression was found in 29% of the squamous 
      cells of well differentiated LSCC, 63% of moderately differentiated and 86% of 
      poorly differentiated, and therefor was significantly associated with 
      histological grade (p=0.000). Nuclear beta-catenin expression appeared in 5% of the 
      cells and was also correlated with the histological grades (p=0.000). In 14.7% of 
      the cells it was localized in the cytoplasm, again correlating with histology 
      (p=0.002). According to this study the expression of beta-catenin is an independent 
      prognostic factor for histological grade and to the tumor differentiation. This 
      appears to reflect a structural association and the role of beta-catenin in tumor 
      progression.
FAU - Barakat, Charif
AU  - Barakat C
AD  - Department of Oral Histology and Pathology , Faculty of Dentistry, University of 
      Damascus, Damascus, Syria E-mail : dr.barakat.sh@gmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Case-Control Studies
MH  - Cell Differentiation
MH  - Cell Nucleus/*metabolism
MH  - Cytoplasm/*metabolism
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lip Neoplasms/*metabolism/pathology
MH  - Mouth/*metabolism/pathology
MH  - Neoplasm Grading
MH  - Prognosis
MH  - beta Catenin/*metabolism
EDAT- 2015/08/01 06:00
MHDA- 2016/05/06 06:00
CRDT- 2015/07/31 06:00
PHST- 2015/07/31 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
AID - 10.7314/apjcp.2015.16.13.5187 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(13):5187-90. doi: 10.7314/apjcp.2015.16.13.5187.