PMID- 26225667
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 13
DP  - 2015
TI  - Hepatitis B Virus Infection Is Associated with Poor Prognosis in Patients with 
      Advanced Non Small Cell Lung Cancer.
PG  - 5285-8
AB  - BACKGROUND: Hepatitis B virus (HBV) infection has been reported to be associated 
      with inferior prognosis in hepatocellular and pancreatic carcinoma cases, but has 
      not been studied with respect to non small cell lung cancer (NSCLC). The purpose 
      of this study was to investigate the prognostic significance of HBV infection in 
      advanced NSCLC patients. MATERIALS AND METHODS: A retrospective cohort of 445 
      advanced NSCLC patients was recruited at our hospital from January 1, 2003 until 
      August 30, 2014. Serum HBV markers were tested by enzyme-linked immunosorbent 
      assay. COX proportional hazards analysis was used to evaluate associations of HBV 
      infection with overall survival (OS). RESULTS: Of 445 patients who were qualified 
      for the study, 68 patients were positive for HBsAg, also considered as HBV 
      infection. Patients in HBsAg negative group were found to have better OS (12.6 
      months [12.2-12.9]) than those in HBsAg positive group (11.30 months [10.8-11.9]; 
      p=0.001). Furthermore, COX multivariate analysis identified HBV infection as an 
      independent prognostic factor for OS (HR 0.740 [0.560, 0.978], p=0.034). 
      CONCLUSIONS: Our study found that HBsAg-positive status was an independent 
      prognostic factor for OS in patients with advanced NSCLC. Future prospective 
      studies are required to confirm our findings.
FAU - Peng, Jie-Wen
AU  - Peng JW
AD  - Department of Medical Oncology, Zhongshan Hospital of Sun Yat-sen University, 
      Zhongshan City People's Hospital, People's Republic of China E-mail : 
      xiazhj1@163.com.
FAU - Liu, Dong-Ying
AU  - Liu DY
FAU - Lin, Gui-Nan
AU  - Lin GN
FAU - Xiao, Jian-jun
AU  - Xiao JJ
FAU - Xia, Zhong-Jun
AU  - Xia ZJ
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/mortality/*pathology/virology
MH  - Carcinoma, Squamous Cell/mortality/*secondary/virology
MH  - China
MH  - Female
MH  - Follow-Up Studies
MH  - Hepatitis B/*complications/virology
MH  - Hepatitis B virus/*pathogenicity
MH  - Humans
MH  - Liver Neoplasms/mortality/*secondary/virology
MH  - Lung Neoplasms/mortality/*pathology/virology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
EDAT- 2015/08/01 06:00
MHDA- 2016/05/11 06:00
CRDT- 2015/07/31 06:00
PHST- 2015/07/31 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
AID - 10.7314/apjcp.2015.16.13.5285 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(13):5285-8. doi: 10.7314/apjcp.2015.16.13.5285.