PMID- 26226673
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20161125
IS  - 0016-254X (Print)
IS  - 0016-254X (Linking)
VI  - 106
IP  - 5
DP  - 2015 May
TI  - [The Effect of Maternal Exposure to Dioxins on the Level of Thyroid Hormone in 
      Developing Pups].
PG  - 127-34
AB  - Maternal exposure to dioxins causes a number of developmental disorders in the 
      offspring. Previous studies have suggested that lactational exposure to 
      2,3,7,8-tetrachlorodizenzo-p-dioxin (TCDD) reduces the pup level of thyroid 
      hormone after weaning, leading to the damage to their development including 
      neural maturation. However, the specificity for age and dioxin congeners as well 
      as dose dependency in terms of a reduction in pup thyroid hormone remains to be 
      clarified. To address this issue, we investigated whether TCDD or 
      2,3,4,7,8-pentachlorodibenzofuran (PenCDF), one of the dioxins which caused 
      'Yusho' incident, affects the status of thyroid hormone during the fetal and 
      neonatal periods. Treating pregnant rats at gestational day (GD)15 with 1 mug/kg 
      TCDD scarcely affected the serum concentration of thyroxine, although a 
      significant reduction by TCDD was detected at limited endpoints [GD21 and 
      postnatal day (PND)21]. In addition, maternal exposure to TCDD (0.05-30 mug/kg) or 
      PenCDF (1-1,000 mug/kg) did not have any change in the serum level of thyroxine in 
      GD20 fetuses even at the maximum dose. Neither the expression of pituitary 
      thyroid-stimulating hormone beta (TSHbeta) nor hypothalamic thyrotropin-releasing 
      hormone was sensitive to TCDD treatment. In pregnant dams, TCDD decreased the 
      serum level of thyroxine at GD20 and 21, while the pituitary expression of TSHbeta 
      was induced. These results suggest that a single administration of dioxins to 
      pregnant rats at GD15 have little effect on the level of thyroxine in the fetuses 
      and infants, while a reduced level of this hormone observed in the offspring at 
      GD21 and PND21 and pregnant dams at GD20 and 21.
FAU - Hattori, Yukiko
AU  - Hattori Y
FAU - Takeda, Tomoki
AU  - Takeda T
FAU - Taura, Junki
AU  - Taura J
FAU - Kuroki, Hiroaki
AU  - Kuroki H
FAU - Ishii, Yuji
AU  - Ishii Y
FAU - Yamada, Hideyuki
AU  - Yamada H
LA  - jpn
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Fukuoka Igaku Zasshi
JT  - Fukuoka igaku zasshi = Hukuoka acta medica
JID - 9423321
RN  - 0 (Dioxins)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Dioxins/*toxicity
MH  - Female
MH  - Fetus/*drug effects
MH  - Male
MH  - Polychlorinated Dibenzodioxins/toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Thyroxine/blood
EDAT- 2015/08/01 06:00
MHDA- 2015/09/09 06:00
CRDT- 2015/08/01 06:00
PHST- 2015/08/01 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
PST - ppublish
SO  - Fukuoka Igaku Zasshi. 2015 May;106(5):127-34.