PMID- 26226842
OWN - NLM
STAT- MEDLINE
DCOM- 20160818
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 28
IP  - 10
DP  - 2015 Oct
TI  - Genomic and immunohistochemical profiles of enteropathy-associated T-cell 
      lymphoma in Japan.
PG  - 1286-96
LID - 10.1038/modpathol.2015.85 [doi]
AB  - Enteropathy-associated T-cell lymphoma (EATL) is a rare primary T-cell lymphoma 
      of the digestive tract. EATL is classified as either Type I, which is frequently 
      associated with and thought to arise from celiac disease and is primarily 
      observed in Northern Europe, and Type II, which occurs de novo and is distributed 
      all over the world with predominance in Asia. The pathogenesis of EATL in Asia is 
      unknown. We aimed to clarify the histological and genomic profiles of EATL in 
      Japan in a homogeneous series of 20 cases. The cases were characterized by 
      immunohistochemistry, high-resolution oligonucleotide microarray, and 
      fluorescence in situ hybridization (FISH) at five different loci: 1q21.3 (CKS1B), 
      6q16.3 (HACE1), 7p22.3 (MAFK), 9q33.3 (PPP6C), and 9q34.3 (ASS1, CARD9) using 
      formalin-fixed paraffin-embedded sections. The histological appearance of EATL 
      ranged from medium- to large-sized cells in 13 cases (65%), small- to 
      medium-sized cells in five cases (25%), and medium-sized in two cases (10%). The 
      immunophenotype was CD2(+) (60%), CD3varepsilon(+) (100%), CD4(+) (10%), CD7(+) (95%), 
      CD8(+) (80%), CD56(+) (85%), TIA-1(+) (100%), Granzyme B(+) (25%), T-cell 
      receptor (TCR)beta(+) (10%), TCRgamma(+) (35%), TCRgammadelta(+) (50%), and double negative for 
      TCR (six cases, 30%). All cases were EBER(-). The genomic profile showed 
      recurrent copy number gains of 1q32.3, 4p15.1, 5q34, 7q34, 8p11.23, 9q22.31, 
      9q33.2, 9q34.13, and 12p13.31, and losses of 7p14.1. FISH showed 15 patients 
      (75%) with a gain of 9q34.3 with good correlation with array comparative genomic 
      hybridization. EATL in Japan is characterized by non-monomorphic cells with a 
      cytotoxic CD8(+) CD56(+) phenotype similar to EATL Type II. The genomic profile 
      is comparable to EATL of Western countries, with more similarity to Type I (gain 
      of 1q and 5q) rather than Type II (gain of 8q24, including MYC). The 9q34.3 gain 
      was the most frequent change confirmed by FISH irrespective of the cell origin of 
      alphabeta-T-cells and gammadelta-T-cells.
FAU - Tomita, Sakura
AU  - Tomita S
AD  - Department of Pathology, Tokai University, School of Medicine, Isehara, Japan.
FAU - Kikuti, Yara Y
AU  - Kikuti YY
AD  - Department of Pathology, Tokai University, School of Medicine, Isehara, Japan.
FAU - Carreras, Joaquim
AU  - Carreras J
AD  - Department of Pathology, Tokai University, School of Medicine, Isehara, Japan.
FAU - Kojima, Minoru
AU  - Kojima M
AD  - Department of Hematology, Tokai University, School of Medicine, Isehara, Japan.
FAU - Ando, Kiyoshi
AU  - Ando K
AD  - Department of Hematology, Tokai University, School of Medicine, Isehara, Japan.
FAU - Takasaki, Hirotaka
AU  - Takasaki H
AD  - Department of Oncology, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Sakai, Rika
AU  - Sakai R
AD  - Department of Oncology, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Takata, Katsuyoshi
AU  - Takata K
AD  - Department of Pathology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Yoshino, Tadashi
AU  - Yoshino T
AD  - Department of Pathology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Bea, Silvia
AU  - Bea S
AD  - Department of Pathology and Hematopathology Unit, Hospital Clinic Barcelona, 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of 
      Barcelona, Barcelona, Spain.
FAU - Campo, Elias
AU  - Campo E
AUID- ORCID: 0000-0001-9850-9793
AD  - Department of Pathology and Hematopathology Unit, Hospital Clinic Barcelona, 
      Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of 
      Barcelona, Barcelona, Spain.
FAU - Nakamura, Naoya
AU  - Nakamura N
AD  - Department of Pathology, Tokai University, School of Medicine, Isehara, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150731
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Adult
MH  - Aged
MH  - Comparative Genomic Hybridization
MH  - Enteropathy-Associated T-Cell Lymphoma/*genetics/immunology/*pathology
MH  - Female
MH  - Genome, Human
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Oligonucleotide Array Sequence Analysis
EDAT- 2015/08/01 06:00
MHDA- 2016/08/19 06:00
CRDT- 2015/08/01 06:00
PHST- 2015/03/18 00:00 [received]
PHST- 2015/05/26 00:00 [revised]
PHST- 2015/05/27 00:00 [accepted]
PHST- 2015/08/01 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/08/19 06:00 [medline]
AID - S0893-3952(22)01361-8 [pii]
AID - 10.1038/modpathol.2015.85 [doi]
PST - ppublish
SO  - Mod Pathol. 2015 Oct;28(10):1286-96. doi: 10.1038/modpathol.2015.85. Epub 2015 
      Jul 31.