PMID- 26227011
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20151007
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 42
IP  - 7
DP  - 2015 Oct
TI  - Cortical inhibition of laser pain and laser-evoked potentials by non-nociceptive 
      somatosensory input.
PG  - 2407-14
LID - 10.1111/ejn.13035 [doi]
AB  - Although the inhibitory action that tactile stimuli can have on pain is well 
      documented, the precise timing of the interaction between the painful and 
      non-painful stimuli in the central nervous system is unclear. The aim of this 
      study was to investigate this issue by measuring the timing of the amplitude 
      modulation of laser evoked potentials (LEPs) due to conditioning non-painful 
      stimuli. LEPs were recorded from 31 scalp electrodes in 10 healthy subjects after 
      painful stimulation of the right arm (C6-C7 dermatomes). Non-painful electrical 
      stimuli were applied by ring electrodes on the second and third finger of the 
      right hand. Electrical stimuli were delivered at +50, +150, +200 and +250 ms 
      interstimulus intervals (ISIs) after the laser pulses. LEPs obtained without any 
      conditioning stimulation were used as a baseline. As compared to the baseline, 
      non-painful electrical stimulation reduced the amplitude of the vertex N2/P2 LEP 
      component and the laser pain rating when electrical stimuli followed the laser 
      pulses only at +150 and +200 ms ISIs. As at these ISIs the collision between the 
      non-painful and painful input is likely to take place at the cortical level, we 
      can conclude that the late processing of painful (thermal) stimuli is partially 
      inhibited by the processing of non-painful (cutaneous) stimuli within the 
      cerebral cortex. Moreover, our results do not provide evidence that non-painful 
      inputs can inhibit pain at a lower level, including the spinal cord.
CI  - (c) 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Testani, Elisa
AU  - Testani E
AD  - Department of Neurosciences, Catholic University, Rome, Italy.
FAU - Le Pera, Domenica
AU  - Le Pera D
AD  - Department of Neurology, IRCSS S. Raffaele Pisana, Tosinvest-Sanita, Rome, Italy.
FAU - Del Percio, Claudio
AU  - Del Percio C
AD  - EEG Lab, IRCSS S. Raffaele Pisana, Tosinvest-Sanita, Rome, Italy.
FAU - Miliucci, Roberto
AU  - Miliucci R
AD  - Neurology Unit, Ospedale Pediatrico Bambino Gesu, IRCCS, Piazza Sant'Onofrio 4, 
      Rome, 00165, Italy.
FAU - Brancucci, Alfredo
AU  - Brancucci A
AD  - Department of Psychological Sciences, Humanities and the Territory, 'G. 
      d'Annunzio' University of Chieti and Pescara, Chieti, Italy.
FAU - Pazzaglia, Costanza
AU  - Pazzaglia C
AD  - Department of Neurology, Don Carlo Gnocchi Onlus Foundation, Milan, Italy.
FAU - De Armas, Liala
AU  - De Armas L
AD  - Department of Neurology, IRCSS S. Raffaele Pisana, Tosinvest-Sanita, Rome, Italy.
FAU - Babiloni, Claudio
AU  - Babiloni C
AD  - EEG Lab, IRCSS S. Raffaele Pisana, Tosinvest-Sanita, Rome, Italy.
AD  - Department of Physiology and Pharmacology, University of Rome 'La Sapienza', 
      Rome, Italy.
FAU - Rossini, Paolo Maria
AU  - Rossini PM
AD  - Department of Neurosciences, Catholic University, Rome, Italy.
FAU - Valeriani, Massimiliano
AU  - Valeriani M
AD  - Neurology Unit, Ospedale Pediatrico Bambino Gesu, IRCCS, Piazza Sant'Onofrio 4, 
      Rome, 00165, Italy.
AD  - Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20150824
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/*physiology
MH  - Electric Stimulation
MH  - Female
MH  - Humans
MH  - Laser-Evoked Potentials/*physiology
MH  - Male
MH  - Neural Inhibition/*physiology
MH  - Pain Perception/*physiology
MH  - Sensory Gating/*physiology
MH  - Touch Perception/*physiology
OTO - NOTNLM
OT  - cerebral cortex
OT  - gating
OT  - inhibition
OT  - pain
OT  - touch
EDAT- 2015/08/01 06:00
MHDA- 2016/07/21 06:00
CRDT- 2015/08/01 06:00
PHST- 2015/02/04 00:00 [received]
PHST- 2015/06/05 00:00 [revised]
PHST- 2015/07/23 00:00 [accepted]
PHST- 2015/08/01 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - 10.1111/ejn.13035 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2015 Oct;42(7):2407-14. doi: 10.1111/ejn.13035. Epub 2015 Aug 24.